Concept
Myelin
Related publications (96)
DWI Simulation-Assisted Machine Learning Models for Microstructure Estimation
Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Gabriel Girard, Marco Pizzolato, Jonathan Rafael Patino Lopez, Thomas Yu, Muhamed Barakovic
Diffusion MRI (DW-MRI) allows for the detailed exploration of the brain white matter microstructure, with applications in both research and the clinic. However, state-of-the-art methods for microstructure estimation suffer from known limitations, such as t ...
Springer Nature2020Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice
Myelin protein P2 is a peripheral membrane protein of the fatty acid–binding protein family that functions in the formation and maintenance of the peripheral nerve myelin sheath. Several P2 gene mutations cause human Charcot–Marie–Tooth neuropathy, but the ...
2020Model-informed machine learning for multi-component T2 relaxometry
Jean-Philippe Thiran, Meritxell Bach Cuadra, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Elda Fischi Gomez, Marco Pizzolato, Gian Franco Piredda, Thomas Yu, Cristina Granziera, Muhamed Barakovic
Recovering the distribution from multi-echo magnetic resonance (MR) signals is challenging but has high potential as it provides biomarkers characterizing the tissue micro-structure, such as the myelin water fraction (MWF). In this work, we propose to comb ...
2020The Inequality of Neural Destiny: Signatures of Lifecourse Socioeconomic Conditions in Markers of Brain Tissue Myelination and Volume
Maria del Carmen Sandi Perez, Bogdan Draganski, Leyla Loued-Khenissi
Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the neu ...
2020Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship
Jean-Philippe Thiran, Tim Bjørn Dyrby
Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional ...
NATL ACAD SCIENCES2020Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing Brain
Introduction:Preterm infants born before 28 weeks of gestation are at high risk of neurodevelopmental impairment in later life. Cerebral white and gray matter injury is associated with adverse outcomes. High oxygen levels, often unavoidable in neonatal int ...
FRONTIERS MEDIA SA2020Accelerating Multi-Echo GRASE with CAIPIRINHA for Fast and High-Resolution Myelin Water Imaging
Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Marco Pizzolato, Gian Franco Piredda, Reto Meuli
Impaired myelin plays a central role in a wide range of degenerative brain diseases. A method for non-invasive and in vivo assessment of myelin content within clinically acceptable acquisition times is thus desirable. In this work, a 3D multi-echo gradient ...
2019Molecular structure and function of myelin protein P0 in membrane stacking
Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, this is partially enabled by myelin protein zero (P0). Consisting of an im ...
Springer Nature2019Is it feasible to directly access the bundle’s specific myelin content, instead of averaging? A study with Microstructure Informed Tractography
Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Marco Pizzolato, Alessandro Daducci
Diffusion MRI connectometry is a widely used tool to investigate features of structural connectomes that reflect differences in white matter tracks integrity. It consists in averaging microstructural tissues properties (obtained from any voxel-wise map) al ...
2019Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice
Maurizio Molinari, Francesca Bianchi
In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...
2019