Publications related to Autoimmune disease

The role of cGAS in innate immunity and beyond

The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyo ...

2016

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Bruno Lemaitre, Jean Philippe Boquete, Jan Paul Dudzic, Sveta Chakrabarti, Xiaoxue Li, Esther Jeanne Collas

The JAK/STAT pathway is a key signaling pathway in the regulation of development and immunity in metazoans. In contrast to the multiple combinatorial JAK/STAT pathways in mammals, only one canonical JAK/STAT pathway exists in Drosophila. It is activated by ...

Public Library of Science2016

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Melody Swartz, Amanda Waite Lund, Manuel Andreas Fankhauser, Maria Anna Sofia Broggi

Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet ...

Amer Soc Clinical Investigation Inc2016

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Arno Pino Bouwens, Daniel Pawel Szlag, Corinne Berclaz, Jérôme Extermann, Joan Goulley

Aims/hypothesis It is generally accepted that structural and functional quantitative imaging of individual islets would be beneficial to elucidate the pathogenesis of type 1 diabetes. We here introduce functional optical coherence imaging (FOCI) for fast, ...

Springer Verlag2016

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper

Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic diseases to common conditions that are associated with aging. Although associations between aging and mitochondrial function have been identified using mammalian mod ...

Nature Publishing Group2016

Towards the Identification of Disease Signatures

Anastasia Ailamaki, Thomas Heinis, Manolis Karpathiotakis

The identification of biological signatures of diseases will enable the development of new biologically grounded classifications of brain diseases, leading to a new systematic understanding of their causes, and new diagnostic tools. In this paper we presen ...

Springer International Publishing2015

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Jacques Fellay, Istvan Bartha, Christian Hammer

The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,36 ...

Cell Press2015

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid

Kai Johnsson, Rudolf Hovius, Hirohito Haruki, Miriam Grønlund Pedersen

Tryptophan metabolites in the kynurenine pathway are up-regulated by pro-inflammatory cytokines or glucocorticoids, and are linked to anti-inflammatory and immunosuppressive activities. In addition, they are up-regulated in pathologies such as cancer, auto ...

Amer Soc Biochemistry Molecular Biology Inc2015

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Autoimmune disease

Histology Staining Protocol Adaptation and Blood Smear Analysis

The role of cGAS in innate immunity and beyond

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Towards the Identification of Disease Signatures

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid

Graph Chatbot

Chat with Graph Search

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

Histology Staining Protocol Adaptation and Blood Smear Analysis

The role of cGAS in innate immunity and beyond

Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

Longitudinal three-dimensional visualisation of autoimmune diabetes by functional optical coherence imaging

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Towards the Identification of Disease Signatures

Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid