Concept

Amyloid-beta precursor protein

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Amyloid-beta precursor protein

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The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

Gamma-Secretase Dependent Gene Expression

Investigation of Protein Aggregation with a Bloch Surface Wave Sensor

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Self-Assembly of ß-Amyloid Peptides in Cells and on Solid Supports

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

Secondary Structure Assignment of Amyloid-β Peptide Using Chemical Shifts

Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species