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U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate w ...
This thesis introduces a new approach to characterize and evaluate ocular light exposure based on the discovery of novel blue light-sensitive photoreceptors in the human eye. These photoreceptors are the primary mediators of 'non-visual' responses impactin ...
Isogenic cells sharing a common environment present a large degree of heterogeneity in gene expression, and stochasticity inherent to transcription substantially participates in this cell-to-cell variability. Notably, a majority of mammalian genes are tran ...
Visual comfort at workplaces has often been considered in terms of discomfort glare, luminance distribution and task visibility. Besides visual effects, the lighting environment has also impact on human physiology and behaviour. These effects of light are ...
A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We p ...
Encoding of visual information in the brain is retinotopic: Neighboring points in the visual field are mapped onto neighboring photoreceptors in the retina, and these neighborhood relations are maintained in the early stages of cortical processing. However ...
Various biological processes involve the conversion of energy into forms that are usable for chemical transformations and are quantum mechanical in nature. Such processes involve light absorption, excited electronic states formation, excitation energy tran ...
24-hour cycles of light and dark are one of the most significant factors in the built environment that affect human health and wellbeing. In addition to stimulating visual responses, light induces a range of circadian, physiological and behavioral response ...
The transcription factors BMAL1 and CLOCK drive the circadian transcription of clock and clock-controlled genes, such as Dbp. To investigate the kinetics of BMAL1 binding to target genes in real time, we generated a cell line harboring tandem arrays of Dbp ...
Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in i ...
