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Concept
Acetogen
Summary
An acetogen is a microorganism that generates acetate (CH3COO−) as an end product of anaerobic respiration or fermentation. However, this term is usually employed in a narrower sense only to those bacteria and archaea that perform anaerobic respiration and carbon fixation simultaneously through the reductive acetyl coenzyme A (acetyl-CoA) pathway (also known as the Wood-Ljungdahl pathway). These genuine acetogens are also known as "homoacetogens" and they can produce acetyl-CoA (and from that, in most cases, acetate as the end product) from two molecules of carbon dioxide (CO2) and four molecules of molecular hydrogen (H2). This process is known as acetogenesis, and is different from acetate fermentation, although both occur in the absence of molecular oxygen (O2) and produce acetate. Although previously thought that only bacteria are acetogens, some archaea can be considered to be acetogens.
Acetogens are found in a variety of habitats, generally those that are anaerobic (lack oxygen). Acetogens can use a variety of compounds as sources of energy and carbon; the best studied form of acetogenic metabolism involves the use of carbon dioxide as a carbon source and hydrogen as an energy source. Carbon dioxide reduction is carried out by the key enzyme acetyl-CoA synthase. Together with methane-forming archaea, acetogens constitute the last limbs in the anaerobic food web that leads to the production of methane from polymers in the absence of oxygen. Acetogens may represent ancestors of the first bioenergetically active cells in evolution.
Acetogens have diverse metabolic roles, which help them thrive in different environments. One of their metabolic products is acetate which is an important nutrient for the host and its inhabiting microbial community, most seen in termite's guts. Acetogens also serve as "hydrogen sinks" in termite's GI tract. Hydrogen gas inhibits biodegradation and acetogens use up these hydrogen gases in the anaerobic environment to favor the biodegradative capacity of the host by reacting hydrogen gas and carbon dioxide to make acetate.
Official source
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