Concept

Nucleic acid double helix

Related publications (165)

Study of Topoisomerase-DNA Interaction Using Atomic Force Microscopy

The aim of this thesis was to explore the topoisomerase-DNA interactions using atomic force microscopy (AFM) in a liquid environment. Firstly, we present a programmable microcontroller-driven injection system for the exchange of an imaging medium while usi ...

EPFL2012

FM-AFM constant height imaging and force curves: high resolution study of DNA-tip interactions

Giovanni Dietler, Dusan Vobornik, Livan Bladimir Alonso Sarduy, Andrea Cerreta

Interaction of the atomic force microscopy (AFM) tip with the sample can be invasive for soft samples. Frequency Modulation (FM) AFM is gentler because it allows scanning in the non-contact regime where only attractive forces exist between the tip and the ...

Wiley-Blackwell2012

Bifurcated Helical Core Equilibrium States in Tokamaks

Olivier Sauter, Basil Duval, Stefano Coda, Jonathan Graves, Wilfred Anthony Cooper, Holger Reimerdes, Benoît Labit, Antoine Pochelon, David Pfefferlé, Federico David Halpern, Daniele Brunetti, Jonathan Rossel, Mattia Albergante

Tokamaks with weak to moderate reversed central shear in which the minimum rotational transform

q_{min}

is in the neighbourhood of unity can trigger bifurcated MagnetoHydrodynamic (MHD) equilibrium states, one of which is similar to a saturated ideal ...

2012

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

Joachim Lingner

Telomerase is responsible for the immortal phenotype of cancer cells and telomerase inhibition may specifically target cancer cell proliferation. Ligands able to selectively bind to G-quadruplex telomeric DNA have been considered as telomerase inhibitors b ...

2012

Anisotropic Brownian motion in ordered phases of DNA fragments

Using Fluorescence Recovery After Photobleaching, we investigate the Brownian motion of DNA rod-like fragments in two distinct anisotropic phases with a local nematic symmetry. The height of the measurement volume ensures the averaging of the anisotropy of ...

2012

Tightening of DNA knots by supercoiling facilitates their unknotting by type II DNA topoisomerases

Giovanni Dietler, Andrzej Stasiak, Guillaume Witz

Using numerical simulations, we compare properties of knotted DNA molecules that are either torsionally relaxed or supercoiled. We observe that DNA supercoiling tightens knotted portions of DNA molecules and accentuates the difference in curvature between ...

2011

Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Paul Joseph Dyson, Alexey Nazarov

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic acti ...

Oxford University Press2011

Helical core tokamak MHD equilibrium states

Olivier Sauter, Basil Duval, Stefano Coda, Jonathan Graves, Wilfred Anthony Cooper, Holger Reimerdes, Benoît Labit, Antoine Pochelon, Jonathan Rossel, Mattia Albergante

Bifurcated magnetohydrodynamic tokamak equilibrium states with axisymmetric or helical core structure are computed. When a peaked pressure profile is chosen, the helical core structures appear like the {em snakes} that are observed in the JET tokamak. They ...

Caroline Wilkinson2011

2D Cantilever Array with Fixed Geometries and Varying Spring Constants for Life Science Applications

Nico de Rooij, Terunobu Akiyama, Sebastian Gautsch, Peter Vettiger, Frédéric Loizeau, André Meister

We present 2D cantilever arrays for parallel AFM and their fabrication process using a silicon nitride cantilever with molded tip as the base element of the array. They are designed either for (i) force indentation onto living cells and stiffness mapping, ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2011

Enantiopure, monodisperse alleno-acetylenic oligomers, and cyclooligomers

Pablo Rivera Fuentes

Enantiopure 1,3-diethynylallenes were used as monomers in the construction of monodisperse oligomers and cyclooligomers. The open-chain structures show a non-linear increase in the intensity of the chiroptical properties as the no. of monomeric units incre ...

American Chemical Society2011

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Bifurcated Helical Core Equilibrium States in Tokamaks

Tokamaks with weak to moderate reversed central shear in which the minimum rotational transform

q_{min}

is in the neighbourhood of unity can trigger bifurcated MagnetoHydrodynamic (MHD) equilibrium states, one of which is similar to a saturated ideal ...

2012