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The aim of this contribution is to review the application of thermodynamics to live cultures of microbial and other cells and to explore to what extent this may be put to practical use. A major focus is on energy dissipation effects in industrially relevan ...
Huntington's disease (HD), an incurable neurodegenerative disorder, has a complex pathogenesis including protein aggregation and the dysregulation of neuronal transcription and metabolism. Here, we demonstrate that inhibition of sirtuin 2 (SIRT2) achieves ...
Recently, a novel approach has been developed to study gene expression in single cells with high time resolution using RNA Fluorescent In Situ Hybridization (FISH). The technique allows individual mRNAs to be counted with high accuracy in wildtype cells, b ...
Heritable changes to the transcriptome that are independent to changes in the genome are defined as epigenetics. DNA methylation and posttranslational modifications of histones, such as acetylation/deacetylation and methylation/demethylation of lysine resi ...
Sophisticated quality control mechanisms prolong retention of protein-folding intermediates in the endoplasmic reticulum (ER) until maturation while sorting out terminally misfolded polypeptides for ER-associated degradation (ERAD). The presence of structu ...
The giant unicellular macroalgae exhibit an extraordinary wound repair mechanism. The rapid assimilation of cellular contents into an insoluble wound plug prevents detrimental cytoplasmic loss and limits the intrusion of extracellular components which coul ...
Abundant in nature lignocellulosic plant biomass represent a promising, sustainable, source of energy as it can be converted into fuel ethanol through the fermentation of one of its prevalent sugar constituents – xylose. Xylose-utilizing recombinant Saccha ...
Naturally occurring photosynthetic systems use elaborate pathways of self-repair to limit the impact of photo-damage. Here, we demonstrate a complex consisting of two recombinant proteins, phospholipids and a carbon nanotube that mimics this process. The c ...
Within systems biology there is an increasing interest in the stochastic behaviour of biochemical reaction networks. An appropriate stochastic description is provided by the chemical master equation, which represents a continuous-time Markov chain (CTMC). ...
This thesis is devoted to the study of oxygen reduction reaction catalysed by porphyrins at the interface between two immiscible electrolyte solutions (ITIES). Electrochemical and spectrophotometric techniques are introduced to these interfaces in order to ...
