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Recent comparative genomic and other large-scale bioinformatics studies increasingly have been using gene annotations, functional classifications, and complimentary data from the emerging “-omics” disciplines. Indeed, such analyses have better chances to u ...
Malaria is the most devastating parasitic infection killing each year between 1 and 3 million of people. Furthermore this decease has a huge socio-economic impact in affected countries. The emergence of resistance against currently used drug makes the deve ...
Precise information about kinetic properties of enzymes within a biochemical network is a necessary ingredient of any successful metabolic engineering design. Such information inevitably involves uncertainty due to changes in cellular and process parameter ...
Lindane, the gamma-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and alpha-, beta-, and gamma- isomers of HCH were widely used as commercial insecticides in the last half of the 20th century ...
Electron transfer reactions taking place at the surface of dye-sensitized semiconductors are key processes in dye-sensitized solar cells (DSSCs). After light absorption, the excited state of a dye injects an electron into a wide-bandgap semiconductor, usua ...
The article presents DFT calcns. that elucidate the interaction of a redox mediator, iodide/triiodide, and an oxidized org. dye photo-sensitizer, providing electronic structure insight into all steps of the mechanism involved in dye-sensitized solar cells. ...
Experimental techniques in molecular biology have led to the production of enormous amounts of data on the dynamics of cellular processes. The availability of time series data characterizing genomic, proteomic and metabolic systems must be complemented wit ...
A century after the identification of a coenzymatic activity for NAD(+), NAD(+) metabolism has come into the spotlight again due to the potential therapeutic relevance of a set of enzymes whose activity is tightly regulated by the balance between the oxidi ...
Monitoring of metabolic compounds, such as glucose and lactate, is extensively reported in literature, especially for clinical purposes. Instead, the application of such technologies for monitoring metabolites in cell cultures has not been explored. From o ...
The processing of Winked glycans determines secretory protein homeostasis in the eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) are regulated by molecular chaperones and enzymes recruited by specific oligosaccha ...