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A hypothesis (: hypotheses) is a proposed explanation for a phenomenon. For a hypothesis to be a scientific hypothesis, the scientific method requires that one can test it. Scientists generally base scientific hypotheses on previous observations that cannot satisfactorily be explained with the available scientific theories. Even though the words "hypothesis" and "theory" are often used interchangeably, a scientific hypothesis is not the same as a scientific theory. A working hypothesis is a provisionally accepted hypothesis proposed for further research in a process beginning with an educated guess or thought. A different meaning of the term hypothesis is used in formal logic, to denote the antecedent of a proposition; thus in the proposition "If P, then Q", P denotes the hypothesis (or antecedent); Q can be called a consequent. P is the assumption in a (possibly counterfactual) What If question. The adjective hypothetical, meaning "having the nature of a hypothesis", or "being assumed to exist as an immediate consequence of a hypothesis", can refer to any of these meanings of the term "hypothesis". In its ancient usage, hypothesis referred to a summary of the plot of a classical drama. The English word hypothesis comes from the ancient Greek word ὑπόθεσις hypothesis whose literal or etymological sense is "putting or placing under" and hence in extended use has many other meanings including "supposition". In Plato's Meno (86e–87b), Socrates dissects virtue with a method used by mathematicians, that of "investigating from a hypothesis". In this sense, 'hypothesis' refers to a clever idea or to a convenient mathematical approach that simplifies cumbersome calculations. Cardinal Bellarmine gave a famous example of this usage in the warning issued to Galileo in the early 17th century: that he must not treat the motion of the Earth as a reality, but merely as a hypothesis. In common usage in the 21st century, a hypothesis refers to a provisional idea whose merit requires evaluation.

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In science and philosophy, an ad hoc hypothesis is a hypothesis added to a theory in order to save it from being falsified. Often, ad hoc hypothesizing is employed to compensate for anomalies not anticipated by the theory in its unmodified form. Scientists are often skeptical of theories that rely on frequent, unsupported adjustments to sustain them. This is because, if a theorist so chooses, there is no limit to the number of ad hoc hypotheses that they could add. Thus the theory becomes more and more complex, but is never falsified.

A conceptual framework is an analytical tool with several variations and contexts. It can be applied in different categories of work where an overall picture is needed. It is used to make conceptual distinctions and organize ideas. Strong conceptual frameworks capture something real and do this in a way that is easy to remember and apply. Isaiah Berlin used the metaphor of a "fox" and a "hedgehog" to make conceptual distinctions in how important philosophers and authors view the world.

Testability is a primary aspect of Science and the Scientific Method and is a property applying to an empirical hypothesis, involves two components: Falsifiability or defeasibility, which means that counterexamples to the hypothesis are logically possible. The practical feasibility of observing a reproducible series of such counterexamples if they do exist. In short, a hypothesis is testable if there is a possibility of deciding whether it is true or false based on experimentation by anyone.