Publications related to Microbial toxin

Growth control switch by a DNA-damage-inducible toxin–antitoxin system in Caulobacter crescentus

Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay

Bacterial toxin-antitoxin systems (TASs) are thought to respond to various stresses, often inducing growth-arrested (persistent) sub-populations of cells whose housekeeping functions are inhibited. Many such TASs induce this effect through the translation- ...

Nature Publishing Group2016

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

Bruno Lemaitre, Onya Opota

beta-Barrel pore-forming toxins (beta-PFT), a large family of bacterial toxins, are generally secreted as water-soluble monomers and can form oligomeric pores in membranes following proteolytic cleavage and interaction with cell surface receptors. Monalysi ...

American Society for Biochemistry and Molecular Biology2015

Cellular magnetic resonance with iron oxide nanoparticles: long-term persistence of SPIO signal in the CNS after transplanted cell death

Michele De Palma, Mario Leonardo Squadrito, Chiara Cianciaruso

Aim: To study the specificity of cellular MRI based on superparamagnetic iron oxide particles (SPIOs), especially within the CNS. Materials & methods: A microglial cell line was engineered for the expression of a suicide gene, the receptor of diphtheria to ...

Future Medicine Ltd2014

Precise toxigenic ablation of intermediate cells abolishes the "battery" of the cochlear duct

Friedrich Beermann

The extracellular potential of excitable and nonexcitable cells with respect to ground is ∼0 mV. One of the known exceptions in mammals is the cochlear duct, where the potential is ∼80-100 mV, called the endocochlear potential (EP). The EP serves as the "b ...

Society for Neuroscience2013

Did Cholera Toxin Finally Get Caught?

Françoise Gisou van der Goot Grunberg

To orchestrate immune responses, pathogen-recognition receptors have evolved sophisticated strategies to monitor pathogenic processes. In this issue of Cell Host & Microbe, a study by Cho et al. reveals a mechanism of immune recognition that relies on the ...

Cell Press2013

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Lucia Brandi

Anthrax lethal toxin is a classical AB toxin comprised of two components: protective antigen (PA) and lethal factor (LF). Here, we show that following assembly and endocytosis, PA forms a channel that translocates LF, not only into the cytosol, but also in ...

Elsevier2013

Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

Bruno Lemaitre, Onya Opota

Monalysin was recently described as a novel pore-forming toxin (PFT) secreted by the Drosophila pathogen Pseudomonas entomophila. Recombinant monalysin is multimeric in solution, whereas PFTs are supposed to be monomeric until target membrane association. ...

International Union of Crystallography2013

Application of High-Density DNA Resequencing Microarray for Detection and Characterization of Botulinum Neurotoxin-Producing Clostridia

Stewart Cole

Background: Clostridium botulinum and related clostridia express extremely potent toxins known as botulinum neurotoxins (BoNTs) that cause severe, potentially lethal intoxications in humans. These BoNT-producing bacteria are categorized in seven major toxi ...

Public Library of Science2013

The dark sides of capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julie Deuquet Ariosa

Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 ...

2012

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