Concept

Persister cells

Related publications (66)

Localization of adhesins on the surface of a pathogenic bacterial envelope through atomic force microscopy

Sandor Kasas, Giovanni Longo, Petar Stupar

Bacterial adhesion is the first and a significant step in establishing infection. This adhesion normally occurs in the presence of flow of fluids. Therefore, bacterial adhesins must be able to provide high strength interactions with their target surface in ...

Royal Society of Chemistry2015

Dielectrophoresis-based purification of antibiotic-treated bacterial subpopulations

Philippe Renaud, John McKinney, Neeraj Dhar, Rodrigo Martinez Duarte, Meltem Elitas

Persistence of bacteria during antibiotic therapy is a widespread phenomenon, of particular importance in refractory mycobacterial infections such as leprosy and tuberculosis. Persistence is characterized by the phenotypic tolerance of a subpopulation of b ...

Royal Soc Chemistry2014

Disentangling human tolerance and resistance against HIV

Jacques Fellay, Amalio Telenti

In ecology, "disease tolerance" is defined as an evolutionary strategy of hosts against pathogens, characterized by reduced or absent pathogenesis despite high pathogen load. To our knowledge, tolerance has to date not been quantified and disentangled from ...

Public Library Science2014

Improving Bicyclic Peptide Phage Display and Development of Sortase A Inhibitors

Inmaculada Rentero Rebollo

Bicyclic peptide ligands are promising molecules for the development of new therapeutics. They combine advantages from large protein therapeutics and small molecule drugs. Large combinatorial libraries of bicyclic peptides can be generated and screened by ...

EPFL2014

A problem of persistence: still more questions than answers?

John McKinney

The current antibiotic resistance crisis has led to increased pressure to prioritize strategies to tackle the issue, with a strong focus being placed on the development of novel antimicrobials. However, one major obstacle that is often overlooked is persis ...

Nature Publishing Group2013

Interactions of core-shell quantum dots with metal resistant bacterium Cupriavidus metallidurans: Consequences for Cu and Pb removal

Miguel Garcia

In the present study we address the interactions of carboxyl-CdSe/ZnS core/shell quantum dots (QDs), as a model of water dispersible engineered nanoparticles, and metal resistant bacteria Cupriavidus metallidurans, largely used in metal decontamination. Th ...

Elsevier Science Bv2013

Single-Cell Analysis of Mycobacterial Persistence Using Microfabricated Tools

Meltem Elitas

Bacterial cells behave as individuals despite being genetically identical and subject to the same environment. Although the underlying mechanisms of cellular individuality are not well understood, temporal variation of gene expression and protein levels in ...

EPFL2012

Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

Hubert van den Bergh, Patrycja Nowak-Sliwinska

Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism ...

2012

TiO2 nanoparticles suppress Escherichia coli cell division in the absence of UV irradiation in acidic conditions

Juan Kiwi

TiO2 nanoparticles (NPs) activated by UV irradiation are known to have a bactericidal effect. In this study we report the details of TiO2 NPs influence on the colony-forming capacity of E. coli in the dark at pH 4.0-4.5. At this pH the bacterial cells are ...

2012

Characterization of Groundwater Microbial Communities, Dechlorinating Bacteria, and In Situ Biodegradation of Chloroethenes Along a Vertical Gradient

Pierre Rossi, Noam Shani

The variability of hydrogeochemical conditions can affect groundwater microbial communities and the natural attenuation of organic chemicals in contaminated aquifers. It is suspected that in situ biodegradation in anoxic plumes of chloroethenes depends on ...

2011

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