Concept

Nucleic acid

Related publications (113)

Nucleic acid driven sterile inflammation

The etiology of sterile inflammatory conditions is complex and affected by a variety of genetic, environmental and stochastic factors. But despite this overt complexity, progress has been made in elucidating mechanisms underlying disease pathogenesis. An i ...

2013

Controlled hydrogel photopolymerization inside live systems by X-ray irradiation

Giorgio Margaritondo

We successfully demonstrate the in situ formation by X-ray irradiation induced polymerization of a three-dimensional (3D) hydrogel based on poly(ethylene glycol) (PEG) diacrylate (PEG DA), with the option of heparin incorporation to enhance cell adhesion. ...

Royal Society of Chemistry2012

Nanopore Detection of Single Molecule RNAP–DNA Transcription Complex

Aleksandra Radenovic, Erick Antonio Garcia Cordero, Camille Alice Raillon, Floriano Traversi

In the past decade, a number of single-molecule methods have been developed With the aim of investigating single protein and nucleic acid interactions. For the first time we use solid-state nanopore sensing to detect a single E. coli RNAP DNA transcription ...

2012

A quorum sensing-mediated switch contributes to natural transformation of Vibrio cholerae

Melanie Blokesch

There is a fundamental gap in our understanding of how horizontal gene transfer contributes to the enormous range of genetic variations that are observed among bacteria. The objective of our study was to better understand how the acquisition of genetic mat ...

2012

Investigation of Biophysical Properties of Biomolecules by Means of Atomic Force Microscopy

Jae Sun Jeong

Biomolecules are the building blocks of living organisms and perform the most important functions in a biological process. The aim of biophysics is to understand the biological functions of biomolecules in terms of their structure: structure and function o ...

EPFL2012

Microfluidic applications of functionalized magnetic particles for environmental analysis: focus on waterborne pathogen detection

Martinus Gijs

The continuous surveillance of drinking water is extremely important to provide early warning of contamination and to ensure continuous supplies of healthy drinking water. Isolation and detection of a particular type of pathogen present at low concentratio ...

Springer-Verlag2012

Post-translational modification of genetically encoded polypeptide libraries

Christian Heinis, Alessandro Angelini

The genetic encoding of polypeptides with biological display systems enables the facile generation and screening of very large combinatorial libraries of molecules. By post-translationally modifying the encoded polypeptides, chemically and structurally mor ...

Elsevier2011

Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics

Christian Hartinger, Alexey Nazarov, Andrew Douglas Phillips

Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear rut ...

2011

Arrays of 100μm x 100μm dielectric elastomer actuators to strain the single cells

Herbert Shea, Samin Akbari

Dielectric Elastomer Actuators (DEA) are compliant devices capable of generating large percentage strains with sub-second response times. Miniaturizing DEAs is challenging principally because of the need for mu m-scale compliant electrodes. Employing low-e ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2011

DNA extraction from soil samples: Time for high throughput efficacy

Pierre Rossi, Luiz Felippe De Alencastro, Claire Meugnier

Total DNA extraction is the key stage allowing the implementation of various downstream applications in molecular ecology. The widespread application of downstream technologies has led to an increasing demand for highly pure biomolecules. Manual methods an ...

2011

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