Concept

Illegal drug trade

Related publications (33)

Nanoparticle actuated hollow drug delivery vehicles

The trend towards personalized medicine and the long-standing wish to reduce drug consumption and unwanted side effects have been the driving force behind research on drug delivery vehicles that control localization, timing and dose of released cargo. Cont ...

2012

Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)]

Paul Joseph Dyson

The ruthenium-based complex [Ru(eta(6)-p-phenylethacrynate)Cl-2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane), termed ethaRAPTA, is an interesting antitumor compound. The elucidation of the molecular mechanism of drug activity is central to ...

2012

Monitoring of illicit pill distribution networks using an image collection exploration framework

Luc Patiny, Julien Wist

This paper proposes a novel approach for the analysis of illicit tablets based on their visual characteristics. In particular, the paper concentrates on the problem of ecstasy pill seizure profiling and monitoring. The presented method extracts the visual ...

Elsevier Ireland Ltd2012

Multi-panel drugs detection in human serum for personalized therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini

This work focuses on P450 biosensors based on multiwalled carbon nanotubes (MWCNT) and different cytochrome isoforms: 3A4, 2B4, 2C9. The proposed biosensors exhibit enhanced sensitivities and decreased detection limits thanks to carbon nanotubes. The MWCNT ...

Elsevier2011

Multiplexing pH and Temperature in a Molecular Biosensor

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini, Michele Daniel Torre, Daniela De Venuto

Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same ...

2010

Synthetic Studies on Daphmanidin C and Maytenone Based on Biosynthetic Considerations and Natural Product Hybrids as Tools for Quorum Sensing

Adrien Keith Lawrence

The isolation and characterisation of natural products remains a challenge in chemistry owing to nature's magnificent diversity. Natural products or natural product derivatives have always been used in traditional medicine to treat a variety of diseases. T ...

EPFL2010

P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy

Giovanni De Micheli, Sandro Carrara, Andrea Cavallini

Nowadays, the concept of personalized therapy gains momentum. Pharmacogenomics, which represents a first answer to these needs, has the drawback of neglecting some variations of therapy response due to non-genetic factors. The aim of this paper is to inves ...

2010

Nanostructured titania coatings for drug-eluting medical implants

Karin Dittmar

Medical implants delivering drugs are used to ensure efficient medication at body sites, at which the conventional administration of drugs is insufficient. The application of drug-delivery coatings is a beneficial concept for implants exposed to mechanical ...

EPFL2009

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross-resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp)-mediated drug efflux. To address this problem, ...

National Academy of Sciences2008

Forensic Automatic Speaker Recognition

Andrzej Drygajlo

The existence of highly developed and fully automated telephone networks in industrialized countries and the pervasiveness of speech communication technology have resulted in the ever-increasing use of the human voice as an instrument in the commission of ...

2007

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