Concept

Nuclear pore

Related publications (162)

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Johan Auwerx, Kristina Schoonjans, Carlos Canto Alvarez, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis

NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further red ...

Cell Press2013

Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism

Henning Paul-Julius Stahlberg, Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Matteo Thomas Degiacomi

Aerolysin is the founding member of a superfamily of (beta-pore-forming toxins whose pore structure is unknown. We have combined X-ray crystallography, cryo-EM, molecular dynamics and computational modeling to determine the structures of aerolysin mutants ...

Nature Publishing Group2013

Corona protein composition and cytotoxicity evaluation of ultra-small zeolites synthesized from template free precursor suspensions

Cécile Hébert, Emad Oveisi

The toxicity of two types of ultra-small zeolites (8–18 nm) with LTL- and EMT-type structures is reported. Both the LTL- and EMT-type zeolites belong to the same group of molecular sieves; they have large pores (7.1–7.5 Å) and low silica content (Si/Al = 1 ...

Royal Soc Chemistry2013

Replication of Telomeres and the Regulation of Telomerase

Joachim Lingner, Verena Pfeiffer

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome ends from DNA degradation, recombination, and DNA end fusions, and they are important for nuclear architecture. Telomeres provide a mechanism for their replication by semico ...

Cold Spring Harbor Lab Press, Publications Dept2013

Numerical Simulation of Porosity in Cements

Karen Scrivener, Shashank Bishnoi, Quang Huy Do

The pores in cementitious materials, their sizes and connectivity have an important influence on the durability of concrete. Several microstructural models have been developed to simulate the three-dimensional pore network in cement pastes. In this article ...

Springer Netherlands2013

The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

Pierre Gönczy, Coralie Busso

Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference-based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed tha ...

Amer Soc Cell Biology2012

Isolation and Analysis of Regulators Coordinating the Nuclear Cycle with Cytokinesis in Schizosaccharomyces Pombe

Evelyn Lattmann

During the division of a mother cell into two daughter cells the genetic material of the mother cell is replicated and segregated to the daughter cells before the cytoplasm divides into two portions in a process called cytokinesis. In order to maintain the ...

EPFL2012

Ion Binding and Internal Hydration in the Multidrug Resistance Secondary Active Transporter NorM Investigated by Molecular Dynamics Simulations

Ursula Röthlisberger, Pablo Campomanes Ramos, Stefano Vanni

Recently, a 3.65 angstrom resolution structure of the transporter, NorM from the multidrug and toxic compound extrusion family has been determined in the outward-facing conformation. This antiporter uses electrochemical gradients to drive substrate export ...

2012

Increased imaging speed and force sensitivity for bio-applications with small cantilevers using a conventional AFM setup

Georg Fantner

In this study, we demonstrate the increased performance in speed and sensitivity achieved by the use of small AFM cantilevers on a standard AFM system. For this, small rectangular silicon oxynitride cantilevers were utilized to arrive at faster atomic forc ...

Elsevier2012

Towards a molecular architecture of centriole assembly

Pierre Gönczy

The centriole is an evolutionarily conserved macromolecular structure that is crucial for the formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first characterized decades ago with the advent of electron microscopy, reve ...

2012

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