Publications related to Ligand (biochemistry)

Differential peptide binding to CD40 evokes counteractive responses

Giovanni Dietler, Sandor Kasas, Charles Roduit, Livan Bladimir Alonso Sarduy, Bhaskar Saha

The antigen-presenting cell-expressed CD40 is implied in the regulation of counteractive immune responses such as induction of pro-inflammatory and anti-inflammatory cytokines interleukin (IL)-12 and IL-10, respectively. The mechanism of this duality in CD ...

Elsevier2012

Screening of large molecule diversities by phage display

Christian Heinis, Inmaculada Rentero Rebollo

Molecules with tailored binding specificities are needed for many purposes such as the development of therapeutics, the detection and purification of biomolecules or in chemical biology for the study and manipulation of biological systems. With phage displ ...

Schweizerische Chemische Gesellschaft2012

Cell-derived plasma membrane vesicles as minimal cells for analyzing transmembrane signaling

Horst Vogel, Rudolf Hovius, Luigino Grasso, Romain Wyss, Ghérici Hassaïne, Joachim Piguet, Michael Werner

Cellular signalling is classically investigated by measuring optical or electrical properties of single or populations of living cells. Here we show how cell-derived vesicles can be used for anlaysing transmembrane signalling. The vesicles are derived from ...

2012

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metalla ...

2012

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides

Christian Heinis, Alessandro Angelini, Shiyu Chen, Julia Morales Sanfrutos

Combinatorial libraries of structurally diverse peptide macrocycles offer a rich source for the development of high-affinity ligands to targets of interest. In this work we have developed linkers for the generation of genetically encoded bicyclic peptides ...

2012

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

Theo Lasser, Harm-Anton Klok, Zuzana Kadlecova

An optical method is presented that allows the measurement of the triplet lifetime of a fluorescent molecule. This is a characteristic specific to each fluorophore. Based on differences in triplet lifetimes of two fluorescent species (autofluorescence vers ...

Optical Soc Amer2012

Block copolymer-directed assembly of bare metal oxide nanocrystals for energy-related devices

Raffaella Buonsanti

The properties of metal oxide nanocrystals in energy-related devices are strongly dependent on the presence and chem. nature of ligands at their surface, and the architectures they assume in electroactive layers. A comprehensive strategy to control these a ...

American Chemical Society2012

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Pierre Vogel, Somi Reddy Majjigapu, Olivier Michielin

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used co ...

2012

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Ligand (biochemistry)

Differential peptide binding to CD40 evokes counteractive responses

Screening of large molecule diversities by phage display

Cell-derived plasma membrane vesicles as minimal cells for analyzing transmembrane signaling

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

SNAP-tag based FRET Indicator for GABA and Synthetic GABAB Receptor Ligands

Block copolymer-directed assembly of bare metal oxide nanocrystals for energy-related devices

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles

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Chat with Graph Search

Screening of large molecule diversities by phage display

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Block copolymer-directed assembly of bare metal oxide nanocrystals for energy-related devices

Differential peptide binding to CD40 evokes counteractive responses

Assessment of transferrin recycling by Triplet Lifetime Imaging in living cells

SNAP-tag based FRET Indicator for GABA and Synthetic GABAB Receptor Ligands

Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles

Structurally Diverse Cyclisation Linkers Impose Different Backbone Conformations in Bicyclic Peptides

Cell-derived plasma membrane vesicles as minimal cells for analyzing transmembrane signaling

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition