Concept
Amyloid plaques
Related publications (184)
Method of preparation of amyloidogenic protein aggregates and uses thereof
Hilal Lashuel, Galina Limorenko
The invention relates to methods for the preparation of method of preparation of Tau aggregates, including fibrils, fibrillar species, soluble and insoluble oligomeric species, new Tau aggregates and uses thereof. The invention further relates to the uses ...
2024Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates
Grégoire Courtine, Tomislav Milekovic, Flavio Raschella
Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell ...
OXFORD UNIV PRESS2022Following spatial A beta aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics
Anders Meibom, Stéphane Laurent Escrig, Melissa Kathleen Passarelli
beta-Amyloid (A beta) plaque formation is the major pathological hallmark of Alzheimer's disease (AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it precedes other pathological events and cognitive symptoms by decades. ...
AMER ASSOC ADVANCEMENT SCIENCE2021Enhancing mitochondrial quality control to fight neuromuscular degeneration in aging and disease
Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...
EPFL2021