Publications related to Amyloid plaques

Amyloid-beta plaque deposition measured using propagation-based X-ray phase contrast CT imaging

Bernard Schneider, Aurélien Lathuilière, Vanessa Laversenne, Marco Stampanoni

Amyloid beta accumulation into insoluble plaques (A beta p) is known to play a significant role in the pathological process in Alzheimer's disease (AD). The presence of A beta p is also one of the neuropathological hallmarks for the disease. AD final diagn ...

International Union of Crystallography (IUCr)2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Davide Demurtas, Marc Moniatte, Adrian Schmid, Cyntia De Piano, Nikita Rudinskiy, Christophe Fuerer

Amyloid-beta (A beta) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and A beta oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms ...

Elsevier Science Inc2016

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

Andrea Pfeifer, Andreas Muhs, Bing Li

Accumulation of amyloid-beta (A beta) peptides and amyloid plaque deposition in brain is postulated as a cause of Alzheimer's disease (AD). The precise pathological species of A beta remains elusive although evidence suggests soluble oligomers may be prima ...

Nature Publishing Group2016

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Manish Jain

Photodynamic therapy (PDT), which is based on the activation of photosensitizers with light, can be used to reduce plaque burden. We hypothesized that intra-arterial photosensitizer administration and photo-activation will lead to high and rapid accumulati ...

2016

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

Hilal Lashuel, Patrick Droste

Background: Beside neurofibrillary tangles, amyloid plaques are the major histological hallmarks of Alzheimer's disease (AD) being composed of aggregated fibrils of beta-amyloid (A beta). During the underlying fibrillogenic pathway, starting from a surplus ...

Biomed Central Ltd2015

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

Bernard Schneider, Patrick Fraering, Mitko Dimitrov, Sébastien Mosser, Justine Pascual, Alexandre Matz

The deposition of amyloid-beta (Aβ) aggregates in the brain is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from the cleavage of C-terminal fragments of the amyloid precursor protein (APP-CTFs) by γ-secretase, an intramembrane ...

Oxford University Press2015

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Hilal Lashuel, Bruno Claude Daniel Fauvet

Posttranslational modifications (PTMs) serve as molecular switches for regulating protein folding, function, and interactome and have been implicated in the misfolding and amyloid formation by several proteins linked to neurodegenerative diseases, includin ...

2015

Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production

Romain Hamelin, Patrick Fraering, Marc Moniatte, Mitko Dimitrov, Sébastien Mosser, Alexandre Matz, Blanka Halamoda

An important pathological hallmark of Alzheimer's disease (AD) is the deposition of amyloid-beta (A) peptides in the brain parenchyma, leading to neuronal death and impaired learning and memory. The protease -secretase is responsible for the intramembrane ...

Wiley-Blackwell2015

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Amyloid plaques

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Amyloid-beta plaque deposition measured using propagation-based X-ray phase contrast CT imaging

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production

Graph Chatbot

Chat with Graph Search

Discriminative adsorption of amphiphilic monolayer protected gold nanoparticles on amyloid fibers

Amyloid-beta plaque deposition measured using propagation-based X-ray phase contrast CT imaging

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Structural differences of amyloid-beta fibrils revealed by antibodies from phage display

Structure of Crenezumab Complex with A beta Shows Loss of beta-Hairpin

Intra-Arterial Drug and Light Delivery for Photodynamic Therapy Using Visudyne (R): Implication for Atherosclerotic Plaque Treatment

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Identification of new Presenilin-1 phosphosites: implication for gamma-secretase activity and A beta production