Concept

Systematic desensitization

Related publications (12)

Variability is the rule: Neurophysiology and contextual visual processing in schizophrenia

Traditionally, studies in schizophrenia research employ a single experimental paradigm. The results typically demonstrate a significant difference between patients and controls. Subsequent studies aim to describe the underlying abnormal mechanism at the ge ...

EPFL2024

In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder

Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Fear and other anxiety disorders are extraordinarily robust and difficult to treat. Among the most effective treatments for anxiety disorders are exposure-based therapies, during which a patient is repeatedly confronted with the originally fear-eliciting s ...

EPFL2017

The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht, Céline Fournier

Abstract The neural cell adhesion molecule (NCAM) is a key regulator of brain plasticity. Substantial evidence indicates that NCAM is down-regulated by exposure to sustained stress and chronic stress seems to lead to increased aggression. In addition, cons ...

Informa Healthcare2013

Simulating interactions with virtual characters for the treatment of social phobia

Helena Stephanie Grillon Le Gallennec

Virtual Reality (VR) has nowadays become a very useful tool for therapists in the treatment of phobias. Indeed, it allows the simulation of scenarios which are difficult to reproduce in real life. It also allows for a situation to be repeated as much as on ...

EPFL2009

Fear conditioning enhances spontaneous AMPA receptor-mediated synaptic transmission in mouse hippocampal CA1 area

Maria del Carmen Sandi Perez, Lisa Conboy

AMPA receptor-mediated synaptic modifications in the amygdala have been reported to sustain cued fear conditioning. However, the hippocampal formation is also critically involved in fear learning. Therefore, we examined whether fear conditioning is also ac ...

Wiley-Blackwell2009

Virtual reality exposure therapy for social phobia

Bruno Herbelin

This thesis presents researches and experiments performed in collaboration with a psychiatrist in order to validate and improve the use of virtual reality in social phobia psychotherapy. Cognitive and behavioral therapies are strongly based on the exposure ...

EPFL2005

Acute stress-induced impairment of spatial memory is associated with decreased expression of neural cell adhesion molecule in the hippocampus and prefrontal cortex

Maria del Carmen Sandi Perez

BACKGROUND: There is an extensive literature describing how stress disturbs cognitive processing and can exacerbate psychiatric disorders. There is, however, an insufficient understanding of the molecular mechanisms involved in stress effects on brain and ...

2005

Using physiological measures for emotional assessment: A computer-aided tool for cognitive and behavioral therapy

Daniel Thalmann, Bruno Herbelin, Olivier Renault, Helena Stephanie Grillon Le Gallennec

In the context of cognitive and behavioural therapies, the use of immersion technologies to replace classical exposure often improves the therapeutic process. As it is necessary to validate the efficiency of such a technique, both therapists and VR special ...

2004

Stress alleviates reduced expression of cell adhesion molecules (NCAM, L1), and deficits in learning and corticosterone regulation of apolipoprotein E knockout mice

Maria del Carmen Sandi Perez

Cell adhesion molecules (CAMs) involved in synaptic changes underlying learning and memory processes, are implicated in the effect of stress on behavioural performance. The present study was designed to test the hypothesis that (i) expression of CAMs is ap ...

2001

Crystal Structure of the protein drug urate oxidase-inhibitor complex at 2.05 angstrom resolution

The gene coding for urate oxidase, an enzyme that catalyzes the oxidation of uric acid to allantoin, is inactivated in humans. Consequently, urate oxidase is used as a protein drug to overcome severe disorders induced by uric acid accumulation. The structu ...

1997

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