Concept
Systematic desensitization
Publications associées (29)
Variability is the rule: Neurophysiology and contextual visual processing in schizophrenia
Dario Alejandro Gordillo Lopez
Traditionally, studies in schizophrenia research employ a single experimental paradigm. The results typically demonstrate a significant difference between patients and controls. Subsequent studies aim to describe the underlying abnormal mechanism at the ge ...
EPFL2024Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study
Florian Frédéric Vincent Breider, Dominique Grandjean, Guillaume Suarez, Myriam Borgatta
Background: Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air as aerosols and deposit on particulate matter during use by dispersion, e ...
2023Determination of a clinically effective evobrutinib dose: Exposure-response analyses of a phase II relapsing multiple sclerosis study
The pharmacometric analysis of the double-blind, randomized, phase II study (NCT02975349) investigating the safety and efficacy of evobrutinib, explored exposure-response relationships and suitable dosing regimens of evobrutinib for relapsing multiple scle ...
WILEY2022A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes
Kathryn Hess Bellwald, Lida Kanari, Martina Scolamiero
Environmental cues influence the highly dynamic morphology of microglia. Strategies to characterize these changes usually involve user-selected morphometric features, which preclude the identification of a spectrum of context-dependent morphological phenot ...
NATURE PORTFOLIO2022Repeated exposure to tripping like perturbations elicits more precise control and lower toe clearance of the swinging foot during steady walking
Controlling minimum toe clearance (MTC) is considered an important factor in preventing tripping. In the current study, we investigated modifications of neuro-muscular control underlying toe clearance during steady locomotion induced by repeated exposure t ...
ELSEVIER2021Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Fiona Hollis
Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective ...
2018In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder
Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf
Fear and other anxiety disorders are extraordinarily robust and difficult to treat. Among the most effective treatments for anxiety disorders are exposure-based therapies, during which a patient is repeatedly confronted with the originally fear-eliciting s ...
EPFL2017Experimental adaptation of human echovirus 11 to ultraviolet radiation leads to tolerance to disinfection and resistance to ribavirin
Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann, Jeffrey David Jensen, Qingxia Zhong, Hyunjin Shim
Ultraviolet light in the UVC range is a commonly used disinfectant to control viruses in clinical settings and water treatment. Here, we employed an experimental evolution approach to investigate the adaptation of human echovirus 11 to disinfection by UVC, ...
2017Systems Toxicology Approach to Understand the Kinetics of Benzo(a)pyrene Uptake, Biotransformation, and DNA Adduct Formation in a Liver Cell Model
Cell-based models are important for deriving mechanistic information about stress response pathways that have evolved to protect cells from toxic insult, such as exposure to environmental pollutants. One determinant of the stress response is the amount of ...
Amer Chemical Soc2014The interplay of conditional NCAM-knockout and chronic unpredictable stress leads to increased aggression in mice
Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Orbicia Riccio Wicht, Céline Fournier
Abstract The neural cell adhesion molecule (NCAM) is a key regulator of brain plasticity. Substantial evidence indicates that NCAM is down-regulated by exposure to sustained stress and chronic stress seems to lead to increased aggression. In addition, cons ...
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