Concept

Mitotic catastrophe

Related publications (115)

Unraveling the Physiological Role of Capillary Morphogenesis Gene 2 in Health and Disease

Capillary Morphogenesis Gene 2 (CMG2) is a 55kDa single-pass transmembrane protein best described as the main Anthrax Toxin Receptor. However, CMG2 physiological role remains elusive and understanding better its in vivo function was the main objective of m ...

EPFL2015

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression

Michele De Palma, Mario Leonardo Squadrito

microRNAs (miRNAs) are short non-coding RNAs, which regulate gene expression post-transcriptionally and play crucial roles in relevant biological and pathological processes. Here we investigated the putative role of miRNAs in modulating the tumor-initiatin ...

Wiley-Blackwell2015

Centrosomes and cancer: revisiting a long-standing relationship

Pierre Gönczy

Over a century ago, centrosome aberrations were postulated to cause cancer by promoting genome instability. The mechanisms governing centrosome assembly and function are increasingly well understood, allowing for a timely reappraisal of this postulate. Thi ...

Nature Publishing Group2015

Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe

Viesturs Simanis, Andrea Krapp

The Schizosaccharomyces pombe septation initiation network (SIN) is required for cytokinesis during vegetative growth and for spore formation during meiosis. Regulation of the SIN during mitosis has been studied extensively, but less is known about its mei ...

Company of Biologists2014

NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane

Pierre Gönczy, Coralie Busso, Sachin Kotak

The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gai1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper s ...

2014

An impedance-based flow microcytometer for single cell morphology discrimination

Philippe Renaud, Ludovica Colella, Marjan Shaker

Cell shape is a fundamental biological feature, providing specific information about physiological or pathological cellular conditions. Most of the state-of-the-art microfluidic cytometers, however, only allow simple cell analysis, including viability stud ...

Royal Soc Chemistry2014

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis

Viesturs Simanis

Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle, bu ...

Royal Society, The2014

A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

Michaël Unser, Daniel Sage, Viesturs Simanis, Daniel Andreas Schmitter, Anastasia Chasapi, Ioannis Xenarios

Background: The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by a network of signaling proteins ...

Biomed Central Ltd2013

MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression

Pierre Gönczy, Sachin Kotak

Precise positioning of the mitotic spindle determines the correct cell division axis and is crucial for organism development. Spindle positioning is mediated through a cortical machinery by capturing astral microtubules, thereby generating pushing/pulling ...

2013

Centrosomal MPF triggers the mitotic and morphogenetic switches of fission yeast

Viesturs Simanis, Andrea Krapp

Activation of mitosis-promoting factor (MPF) drives mitotic commitment. In human cells active MPF appears first on centrosomes. We show that local activation of MPF on the equivalent organelle of fission yeast, the spindle pole body (SPB), promotes Polo ki ...

Nature Publishing Group2013

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