Concept

Genealogical DNA test

Related publications (55)

Cellularization across eukaryotes: Conserved mechanisms and novel strategies

Many eukaryotes form multinucleated cells during their devel-opment. Some cells persist as such during their lifetime, others choose to cleave each nucleus individually using a specialized cytokinetic process known as cellularization. What is cellula-rizat ...

CURRENT BIOLOGY LTD2023

Conceptualizing Passage-Paysage

Dieter Dietz, Lucia-Nieves Garcia de Jalon Oyarzun, Ruben Alberto Valdez Juarez, Aurèle Pulfer

In this article, we consider the role of landscape as support for an alternative urban mobility scheme and how architecture can help foster a transition towards a low-carbon system. From that point of departure, we trace the genealogical origins of the ter ...

EPFL Press2023

Intrinsic area near the origin for self-similar growth-fragmentations and related random surfaces

We study the behaviour of a natural measure defined on the leaves of the genealogical tree of some branching processes, namely self-similar growth-fragmentation processes. Each particle, or cell, is attributed a positive mass that evolves in continuous tim ...

2022

Human reproduction is regulated by retrotransposons derived from ancient Hominidae-specific viral infections

Didier Trono, Julien Paul André Pontis, Yu Tao

The transcription factor network required for primordial germ cell (PGC) specification is known to diverge in mammals. Here the authors show that hominidae-specific transposable element (TE) LTR5Hs becomes transcriptionally active during PGC specification, ...

NATURE PORTFOLIO2022

PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction

Beat Fierz, Iuliia Boichenko

The Polycomb repressive complexes PRC1, PRC2, and PR-DUB repress target genes by modifying their chromatin. In Drosophila, PRC1 compacts chromatin and monoubiquitinates histone H2A at lysine 118 (H2Aub1), whereas PR-DUB is a major H2Aub1 deubiquitinase, bu ...

2022

The genetic architecture of complex human traits at the dawn of genomic medicine

Olivier Noël Marie Naret

The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine. The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...

EPFL2021

A platform for experimental precision medicine: The extended BXD mouse family

Johan Auwerx, Evan Graehl Williams

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...

CELL PRESS2021

T-cs degradation of ITER TF samples due to fast current discharges

Pierluigi Bruzzone, Kamil Sedlák, Boris Stepanov

Direct current tests performed in the past on the conductor samples of the toroidal field (TF) ITER coils revealed degradation of current sharing temperature, T-cs. The degradation progresses with repetitive electromagnetic loading, and also with thermal c ...

IOP PUBLISHING LTD2021

Optimization of MEW instrument components and their assembly

Jianan Mao

In recent years, a new additive manufacturing technology Melt Electrowriting (MEW) has become attractive, especially for biomedical applications, and it has potential in many other fields as well. In order to carry out an in-depth study of melt electrowrit ...

2021

Architecture in the Data-driven City

Frederick Peter Ortner

In the last ten years, new sources of urban big data have made it possible for algorithms to increasingly control how the city is perceived, understood and managed by its inhabitants; this is the data-driven city. New efforts in the social sciences, like ...

EPFL2019

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