Concept
Ploidy
Related publications (26)
Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning
Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...
EPFL2023Whole-genome doubling drives oncogenic loss of chromatin segregation
Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Ruxandra-Andreea Lambuta, Juan Diaz Miyar, Giovanni Ciriello
Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies(1-8). However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotyp ...
NATURE PORTFOLIO2023Enhancing developmental rate and quality of mouse single blastomeres into blastocysts using a microplatform
Philippe Renaud, Leila Montazeri, Hanie Kavand
The present work reports the beneficial effects of using a microplatform on the development of mouse single blastomeres (SBs) to the blastocyst stage. Development of blastocysts from SBs separated from two‐ and four‐cell stage embryos (two‐ and four‐cell S ...
2018Detecting and Quantifying Changing Selection Intensities from Time-Sampled Polymorphism Data
Jeffrey David Jensen, Matthieu Foll, Sebastian Matuszewski, Stefan Jean Laurent, Hyunjin Shim
During his well-known debate with Fisher regarding the phenotypic dataset of Panaxia dominula, Wright suggested fluctuating selection as a potential explanation for the observed change in allele frequencies. This model has since been invoked in a number of ...
Genetics Society of America2016Possibilities in Germ Cell Research: An Engineering Insight
Omid Mashinchian, Morteza Mahmoudi
Germ cells (GCs) are responsible for fertility and disruptions in their development or function cause infertility. However, current knowledge about the diverse mechanisms involved in GC development and function is still in its infancy. This is mainly becau ...
Elsevier Science London2015Whole genome duplications and recruitment of ecologically relevant genes in alpine Mustards
Stéphane Joost, Kevin Leempoel, Béatrice North
Polyploid taxa represent excellent models to address the underpinnings of genome evolution and the building up of new species in heterogeneous environments. Here, we present an overview of recent works in the alpine Biscutella laevigata autopolyploid compl ...
2015Effects of ploidy and sex-locus genotype on gene expression patterns in the fire ant Solenopsis invicta
Chitsanu Khurewathanakul, Oksana Riba Grognuz, Laurent Keller
Males in many animal species differ greatly from females in morphology, physiology and behaviour. Ants, bees and wasps have a haplodiploid mechanism of sex determination whereby unfertilized eggs become males while fertilized eggs become females. However, ...
Royal Soc2014Multiscale Spatial Organization of RNA Polymerase in Escherichia coli
Nucleic acid synthesis is spatially organized in many organisms. In bacteria, however, the spatial distribution of transcription remains obscure, owing largely to the diffraction limit of conventional light microscopy (200-300 nm). Here, we use photoactiva ...
Cell Press2013A Finite Population Model of Molecular Evolution: Theory and Computation
This article is concerned with the evolution of haploid organisms that reproduce asexually. In a seminal piece of work, Eigen and coauthors proposed the quasispecies model in an attempt to understand such an evolutionary process. Their work has impacted an ...
Mary Ann Liebert2012Analysis of centriole elimination during C. elegans oogenesis
Pierre Gönczy, Graham Knott, Petr Strnad, Lukas von Tobel, Tamara Mikeladze-Dvali
Centrosomes are the principal microtubule organizing centers (MTOCs) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated, notably to ensure bipolar spindle formation an ...
2012