Concept

Carcinogenesis

Related publications (145)

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression

Michele De Palma, Mario Leonardo Squadrito

microRNAs (miRNAs) are short non-coding RNAs, which regulate gene expression post-transcriptionally and play crucial roles in relevant biological and pathological processes. Here we investigated the putative role of miRNAs in modulating the tumor-initiatin ...

Wiley-Blackwell2015

GLUT1 and GLUT3 in non-small cell lung cancer

Mark Jonathan Masin

While altered metabolism is a well-established tumor cell trait, the specifics of metabolic rewiring during cancer development and progression are yet to be fully understood. The Warburg effect, or aerobic glycolysis, has been described in a wide array of ...

EPFL2015

MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Yiming Cao

Recent advances in cancer biology have emerged important roles for microRNAs (miRNAs) in regulating tumor responses. However, their function in mediating intercellular communication within the tumor microenvironment is thus far poorly explored. Here, we fo ...

Nature Publishing Group2015

Overcoming inefficient secretion of recombinant VEGF-C in baculovirus expression vector system by simple purification of the protein from cell lysate

Witold Waldemar Kilarski

The first reports about successfully expressed recombinant proteins with the use of a baculovirus vector were published over 30 years ago. Despite the long time of refining this expression system, early problems with the production of baculovirus-derived s ...

Academic Press Inc Elsevier Science2015

Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenation

Julien Dorier, Yannis Burnier, Fabrizio Benedetti, Andrzej Stasiak

Due to the helical structure of DNA the process of DNA replication is topologically complex. Freshly replicated DNA molecules are catenated with each other and are frequently knotted. For proper functioning of DNA it is necessary to remove all of these ent ...

Oxford University Press2015

Improving tumor heterogeneity MRI assessment with histograms

Nathalie Just

By definition, tumours are heterogeneous. They are defined by marked differences in cells, microenvironmental factors (oxygenation levels, pH, VEGF, VPF and TGF-α) metabolism, vasculature, structure and function that in turn translate into heterogeneous dr ...

Nature Publishing Group2014

The in situ light microenvironment of corals

Michael Kühl

We used a novel diver-operated microsensor system to collect in situ spectrally resolved light fields on corals with a micrometer spatial resolution. The light microenvironment differed between polyp and coenosarc tissues with scalar irradiance (400-700 nm ...

Amer Soc Limnology Oceanography2014

Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents

Paul Joseph Dyson, Tina Riedel

New polynuclear organometallic Platinum Group Metal (PGM) complexes containing di- and tripyridyl ester ligands have been synthesised and characterised using analytical and spectroscopic techniques including H-1, C-13 NMR and infrared spectroscopy. Reactio ...

2014

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

Efthymia Vokali, Jeffrey Alan Hubbell, Melody Swartz, Amanda Waite Lund, Susan Thomas

Accumulating evidence implicates the tumor-draining lymph node (TDLN) in tumor-induced immune escape, as it drains regulatory molecules and leukocytes from the tumor microenvironment. We asked whether targeted delivery of adjuvant to the TDLN, presumably a ...

Elsevier Sci Ltd2014

Mutator/hypermutable fetal/juvenile metakaryotic stem cells and human colorectal carcinogenesis

Stephan Morgenthaler, Paul Refinetti

Adult age-specific colorectal cancer incidence rates increase exponentially from maturity, reach a maximum, then decline in extreme old age. Armitage and Doll (1) postulated that the exponential increase resulted from “n” mutations occurring throughout adu ...

2013

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