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Background: Protein variability can now be studied by measuring high-resolution tolerance-to-substitution maps and fitness landscapes in saturated mutational libraries. But these rich and expensive datasets are typically interpreted coarsely, restricting d ...
Protein nanopores offer an inexpensive, label-free method of analysing single oligonucleotides. The sensitivity of the approach is largely determined by the characteristics of the pore-forming protein employed, and typically relies on nanopores that have b ...
The current state of the art in RDF Stream Processing (RSP) proposes several models and implementations to combine Semantic Web technologies with Data Stream Management System (DSMS) operators like windows. Meanwhile, only a few solutions combine Semantic ...
The gene family-free framework for comparative genomics aims at developing methods for gene order analysis that do not require prior gene family assignment, but work directly on a sequence similarity graph. We present a model for constructing a median of t ...
The complex mechanisms involved in cellular processes have been increasingly understood this past century and the central role of the DNA molecule has been recognized. The base pair sequence along a DNA fragment is observed not only to encode the genomic i ...
Amongst the substances found in any living organism one of the most central in the workings of each living cell is deoxyribonucleic acid (DNA). For that reason it has been the subject of research in many of its aspects. These range from DNA sequencing to a ...
Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multiprotein complexes and to enable signal transduction in various pathways. Functional interactions between proteins result in coevolution betwee ...
Proceedings of the National Academy of Sciences2016
Networks are central in the modeling and analysis of many large-scale human and technical systems, and they have applications in diverse fields such as computer science, biology, social sciences, and economics. Recently, network mining has been an active a ...
We prove that a general condition introduced by Colombo and Gobbino to study limits of curves of maximal slope allows us to characterize also minimizing movements along a sequence of functionals as curves of maximal slope of a limit functional. ...
In clinical genomics, the continuous evolution of bioinformatic algorithms and sequencing platforms makes it beneficial to store patients' complete aligned genomic data in addition to variant calls relative to a reference sequence. Due to the large size of ...
