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Concept
Pars reticulata
Summary
The pars reticulata (SNpr) is a portion of the substantia nigra and is located lateral to the pars compacta. Most of the neurons that project out of the pars reticulata are inhibitory GABAergic neurons (i.e., these neurons release GABA, which is an inhibitory neurotransmitter).
Neurons in the pars reticulata are much less densely packed than those in the pars compacta (they were sometimes named pars diffusa). They are smaller and thinner than the dopaminergic neurons and conversely identical and morphologically similar to the pallidal neurons (see primate basal ganglia). Their dendrites as well as the pallidal are preferentially perpendicular to the striatal afferents. The massive striatal afferents correspond to the medial end of the nigrostriatal bundle. Nigral neurons have the same peculiar synaptology with the striatal axonal endings. They make connections with the dopamine neurons of the pars compacta whose long dendrites plunge deeply in the pars reticulata. The neurons of the pars reticulata produce the neurotransmitter gamma-aminobutyric acid (GABA).
The neurons of the pars reticulata through the nigrothalamic bundle send axons to a particular part of the motor thalamus. The nigral territory corresponds to the nucleus ventralis anterior (VA) (see also List of thalamic nuclei) (different from the pallidal VO). VA is the origin of one output of the basal ganglia system. It sends axons to the frontal and oculomotor cortex. In addition the pars reticulata sends neurons to the pars parafascicularis of the central region of the thalamus and to the pedunculopontine complex).
The particularity of the pars lateralis is to send its axons to the superior colliculus, which is a too minimized output of the basal ganglia system.
The neurons of the pars reticulata are fast-spiking pacemakers, generating action potentials in the absence of synaptic input. In primates they discharge at a mean rate of 68 Hz in contrast to dopaminergic neurons (below 8 Hz).
Official source
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