Publications related to Heparin

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Christian Heinis, Xinjian Ji, Edward Jeffrey Will, Anne Sofie Luise Zarda, Alessandro Angelini, Alexander Lund Nielsen, Manuel Leonardo Merz, Mischa Schüttel, Ganesh Kumar Mothukuri, Zsolt Bognár

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Wiley-V C H Verlag Gmbh2024

Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism

Francesco Stellacci, Matteo Gasbarri, Valeria Cagno

Heparin has been known to be a broad-spectrum inhibitor of viral infection for almost 70 years, and it has been used as a medication for almost 90 years due to its anticoagulant effect. This nontoxic biocompatible polymer efficiently binds to many types of ...

AMER CHEMICAL SOC2022

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Patrick Andreas Gonschorek, Simon Jan Middendorp, Christina Lamers

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

2020

SARS-CoV-2 Inhibition by Sulfonated Compounds

Francesco Stellacci, Matteo Gasbarri, Valeria Cagno

Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) depends on angiotensin converting enzyme 2 (ACE2) for cellular entry, but it might also rely on attachment receptors such as heparan sulfates. Several groups have recently demonstrated a ...

2020

Modified cyclodextrins as broad-spectrum antivirals

Francesco Stellacci, Natalia Gasilova, Matteo Gasbarri, Valeria Cagno, Samuel Thomas Jones, Matej Janecek

Viral infections kill millions of people and new antivirals are needed. Nontoxic drugs that irreversibly inhibit viruses (virucidal) are postulated to be ideal. Unfortunately, all virucidal molecules described to date are cytotoxic. We recently developed n ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Carbohydrate stabilization extends the kinetic limits of chemical polysaccharide depolymerization

Jeremy Luterbacher, Masoud Talebi Amiri, Ydna Marie Questell-Santiago, Raquel Zambrano Varela

Polysaccharide depolymerization is an essential step for valorizing lignocellulosic biomass. In inexpensive systems such as pure water or dilute acid mixtures, carbohydrate monomer degradation rates exceed hemicellulose—and especially cellulose—depolymeriz ...

2018

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Pierre Vogel, George Coukos, Somi Reddy Majjigapu, Olivier Michielin

Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diffi ...

Pergamon-Elsevier Science Ltd2016

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Pierre Vogel, Gerardo Turcatti, Marc Chambon, Somi Reddy Majjigapu, Olivier Michielin

Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulator of immune responses and therefore an important therapeutic target for the treatment of diseases that involve pathological immune escape, such as cancer. Here, we describe a robust and sensitive high-t ...

Elsevier France-Editions Scientifiques Medicales Elsevier2014

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Heparin

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

SARS-CoV-2 Inhibition by Sulfonated Compounds

Modified cyclodextrins as broad-spectrum antivirals

Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution

Carbohydrate stabilization extends the kinetic limits of chemical polysaccharide depolymerization

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Graph Chatbot

Chat with Graph Search

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Polyanionic Amphiphilic Dendritic Polyglycerols as Broad-Spectrum Viral Inhibitors with a Virucidal Mechanism

Carbohydrate stabilization extends the kinetic limits of chemical polysaccharide depolymerization

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Modified cyclodextrins as broad-spectrum antivirals

SARS-CoV-2 Inhibition by Sulfonated Compounds

Development of cyclic peptide inhibitors of coagulation factor XIa for safer anticoagulation

Patchy Amphiphilic Dendrimers Bind Adenovirus and Control Its Host Interactions and in Vivo Distribution