Publications related to Regulatory sequence

Maria del Carmen Sandi Perez, Michael van der Kooij

The organization of individuals in social hierarchies is ubiquitous in social species. Although the evolution of dominance at the population level is constrained by its interactive character, selective breeding shows that dominance and subordination can be ...

2015

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Homing endonucleases are useful tools for genome modification because of their capability to recognize and cleave specifically large DNA targets. These endonucleases generate a DNA double strand break that can be repaired by the DNA damage response machine ...

American Society for Biochemistry and Molecular Biology2015

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Johan Auwerx, Eija Riitta Pirinen

PPAR gamma-dependent gene expression during adipogenesis is facilitated by ADP-ribosyltransferase D-type 1 (ARTD1; PARP1)-catalyzed poly-ADP-ribose (PAR) formation. Adipogenesis is accompanied by a dynamic modulation of the chromatin landscape at PPAR gamm ...

Oxford University Press2015

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

John Maddocks, Marco Pasi

Microsecond molecular dynamics simulations of B-DNA oligomers carried out in an aqueous environment with a physiological salt concentration enable us to perform a detailed analysis of how potassium ions interact with the double helix. The oligomers studied ...

Oxford University Press2015

Limits and patterns of cytomegalovirus genomic diversity in humans

Jeffrey David Jensen, Cornelia Pokalyuk

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans. To address this deficiency, we analyzed genomic diversity among congeni ...

Natl Acad Sciences2015

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

Jacques Rougemont, Philippe Jacquet

Previous studies indicate that eukaryotic promoters display a stereotypical chromatin landscape characterized by a well-positioned +1 nucleosome near the transcription start site and an upstream 1 nucleosome that together demarcate a nucleosome-free (or -d ...

Elsevier2015

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Daniel Constam, Benjamin Marcel Daniel Rothé, Lucía Carolina Leal Esteban, Séverine Marguerite Urfer, Florian Urs Bernet

Loss of the RNA-binding protein Bicaudal-C (Bicc1) provokes renal and pancreatic cysts as well as ectopic Wnt/beta-catenin signaling during visceral left-right patterning. Renal cysts are linked to defective silencing of Bicc1 target mRNAs, including adeny ...

American Society for Microbiology2015

Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion

Freddy Radtke

Cancer-associated fibroblasts (CAF) play a crucial role in regulating cancer progression, yet the molecular determinant that governs the tumor regulatory role of CAF remains unknown. Using a mouse melanoma model in which exogenous melanoma cells were graft ...

Public Library of Science2015

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Regulatory sequence

The genetics of social hierarchies

Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

Limits and patterns of cytomegalovirus genomic diversity in humans

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Phage Selection of Bicyclic Peptides and High-Throughput Screening of Chemical Compounds for the Identification of Novel Inhibitors of the Notch Pathway

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion

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Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold

Nucleosome Stability Distinguishes Two Different Promoter Types at All Protein-Coding Genes in Yeast

The genetics of social hierarchies

Notch1 Pathway Activity Determines the Regulatory Role of Cancer-Associated Fibroblasts in Melanoma Growth and Invasion

ARTD1-induced poly-ADP-ribose formation enhances PPAR gamma ligand binding and co-factor exchange

Analyzing ion distributions around DNA: sequence-dependence of potassium ion distributions from microsecond molecular dynamics

Bicc1 Polymerization Regulates the Localization and Silencing of Bound mRNA

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

Phage Selection of Bicyclic Peptides and High-Throughput Screening of Chemical Compounds for the Identification of Novel Inhibitors of the Notch Pathway

Limits and patterns of cytomegalovirus genomic diversity in humans