Publications related to Tumor necrosis factor

Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage

Paul Joseph Dyson, Romain Hamelin, Florence Armand, Isabelle Mireille Claude Schepens, Gianni Sava

Lysozyme is one of the most important anti-bacterial effectors in the innate immune system of animals. Besides its direct antibacterial enzymatic activity, lysozyme displays other biological properties, pointing toward a significant anti-inflammatory effec ...

2019

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Davide Demurtas, Romain Hamelin, Melody Swartz, Lambert Charles François Potin, Patricia Corthésy Henrioud, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Léa Maillat, Alexandre Harari

Liquid biopsies allow monitoring of cancer progression and detection of relapse, but reliable biomarkers in melanoma are lacking. Because secreted factors preferentially drain to lymphatic vessels before dilution in the blood, we hypothesized that lymph sh ...

ROCKEFELLER UNIV PRESS2019

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

Nicola Harris, Lalit Kumar Dubey

Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5(+) dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of ...

CELL PRESS2019

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Michele De Palma, Alan Nicolas Thierry Guichard, Mario Leonardo Squadrito, Chiara Cianciaruso, Esra Güç, Ioanna Keklikoglou, Antonino Cassarà

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can ...

2019

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Bruno Lemaitre, Jean Philippe Boquete, Zongzhao Zhai

Intestinal infection triggers potent immune responses to combat pathogens and concomitantly drives epithelial renewal to maintain barrier integrity. Current models propose that epithelial renewal is primarily driven by damage caused by reactive oxygen spec ...

2018

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

Michele De Palma, Céline Wyser Rmili, Ece Kadioglu, Nicolo Rigamonti, Damya Laoui, Antonino Cassarà

Pathological angiogenesis is a hallmark of cancer and a therapeutic target. Vascular endothelial growth factor A (VEGFA) and angiopoietin-2 (ANGPT2; also known as ANG2) are proangiogenic cytokines that sustain tumor angiogenesis and limit antitumor immunit ...

American Association for the Advancement of Science2017

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors

Michele De Palma, Ece Kadioglu

Tumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation and metastasis, which can offset the effects of chemotherapy, radiation, and anti-angiogenic therapy. Here, we show that the kinase switch contro ...

Amer Assoc Cancer Research2017

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Nicola Harris, Lalit Kumar Dubey, Praneeth Karempudi

Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LT beta R) signalin ...

Springer Nature2017

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Tumor necrosis factor

Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

A Human Liver-on-a-Chip Platform for Modeling Nonalcoholic Fatty Liver Disease

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

In vitro fate mapping of stem cell development at the single cell level

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

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A Human Liver-on-a-Chip Platform for Modeling Nonalcoholic Fatty Liver Disease

Lysozyme-Induced Transcriptional Regulation of TNF-alpha Pathway Genes in Cells of the Monocyte Lineage

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

IL-4R alpha-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

In vitro fate mapping of stem cell development at the single cell level

Interactions between fibroblastic reticular cells and B cells promote mesenteric lymph node lymphangiogenesis

Cell-Specific Imd-NF-κB Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors