Concept

Stromal cell

Related publications (185)

Identification of a Novel Wnt Inhibitor

Cancer cells are embedded in a microenvironment composed of stromal cells, such as fibroblasts, endothelial cells, infiltrating immune cells, as well as non-cellular compartments such as the extracellular matrix and secreted soluble factors. For successful ...

EPFL2012

Inhibition of Fibroblast Growth by Notch1 Signaling Is Mediated by Induction of Wnt11-Dependent WISP-1

Freddy Radtke, Jialin Zhang, Yurong Tan

Fibroblasts are an integral component of stroma and important source of growth factors and extracellular matrix (ECM). They play a prominent role in maintaining tissue homeostasis and in wound healing and tumor growth. Notch signaling regulates biological ...

Public Library of Science2012

Optimization of the Asymmetric Intermediate Reflector Morphology for High Stabilized Efficiency Thin n-i-p Micromorph Solar Cells

Christophe Ballif, Franz-Josef Haug, Matthieu Despeisse, Mathieu Gérard Boccard, Sylvain Nicolay, Grégory Bugnon, Laura Ding, Gaetano Parascandolo, Simon Hänni, Céline Pahud, Rémi Biron

This paper focuses on our latest progress in n-i-p thinmicromorph solar-cell fabrication using textured back reflectors and asymmetric intermediate reflectors, both deposited by lowpressure chemical vapor deposition of zinc oxide.We then present microcryst ...

Ieee-Inst Electrical Electronics Engineers Inc2012

Development of high band gap protocrystalline material for p-i-n thin film silicon solar cells

Fabio Maurizio

High band gap thin film silicon solar cells are of high interest for the use as top cell in triple junctions solar cells. Protocrystalline silicon, in the transition phase between amorphous and microcrystalline silicon, is such a high band gap material. Du ...

2012

MiR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

Mario Leonardo Squadrito, Ferdinando Pucci

Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated macrophages (TAMs), which are endowed with tissue-remodeling, proangiogenic, and protumoral ...

Cell Press2012

Regulation of tumor invasion by interstitial fluid flow

Melody Swartz, Adrian Chung-Kai Shieh

The importance of the tumor microenvironment in cancer progression is undisputed, yet the significance of biophysical forces in the microenvironment remains poorly understood. Interstitial fluid flow is a nearly ubiquitous and physiologically relevant biop ...

2011

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts

Melody Swartz, Boris Hinz, Adrian Chung-Kai Shieh

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how ...

American Association for Cancer Research2011

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling

Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marro ...

2011

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity

Nicola Harris

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and n ...

Elsevier2011

Lack of IL-2 in PPAR-alpha deficient mice triggers allergic contact dermatitis by affecting regulatory T cells

Johan Auwerx, Kristina Schoonjans

The aim of the present work was to decipher the cellular basis of the immuno-regulatory role of peroxisome proliferator-activated receptor (PPAR)-alpha in cutaneous hypersensitivity reactions. After challenge with a contact allergen, we observed augmented ...

2011

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