A time temperature indicator (TTI) is a device or smart label that shows the accumulated time-temperature history of a product. Time temperature indicators are commonly used on food, pharmaceutical, and medical products to indicate exposure to excessive temperature (and time at temperature). In contrast, a temperature data logger measures and records the temperatures for a specified time period. The digital data can be downloaded and analyzed. The basic types of time-temperature indicators include: Partial history indicators: These are time-temperature indicators that provide a visual indication of whether a product has been exposed to temperatures outside the recommended range during a specific portion of its life cycle. Full history indicators: Unlike partial history indicators, these give an indication of whether the product has been exposed to temperatures outside the recommended range during the entire life cycle. Critical temperature indicators: These monitor a critical temperature threshold that, if exceeded, may cause irreversible damage to the product. Digital temperature data loggers are available to indicate the full temperature history of a shipment to help identify the time period that out-of-tolerance temperatures were encountered. This temperature history can be used to calculate the loss of shelf life or the likelihood of spoilage. These small recorders are also used to identify the time (and thus location) of a shipment when the problem occurred, which allows for corrective action. There are a large number of different time temperature indicators available in the market, based on different technologies. To the degree that these physical changes in the indicator match the degradation rate of the food, the indicator can help indicate probable food degradation. Enzyme-based TTIs: an enzyme changes the color of the dye on a piece of filter paper as time passes Microbe-based TTIs: a mixture containing dye and bacteria changes color as bacteria grow and chemically changes the dye Digital TTIs: a miniature temperature data logger can be attached to the item.