Concept

Focal adhesion

Related publications (128)

Design, fabrication, and characterization of a composite scaffold for bone tissue engineering

Melody Swartz, Alice Anna Tomei, Federica Boschetti

Poly(lactide-co-glycolide) (PLGA) scaffolds have been successfully used in bone tissue engineering, with or without hydroxyapatite (HA) and with a macroporosity given either by simple PLGA sphere packaging and/or by leaching out NaCI. The objective of this ...

Wichtig Editore2008

The increase in protein contour length depends on mechanical unfolding conditions

László Forró, Andrzej Kulik

Many proteins in alive organisms have a domain structure providing them the possibility to reversible unfolding, which seems to play an essential role in those processes occurring in tissues which are controlled by mechanical cellular tension. In this work ...

2008

A point-wise model of adhesion suitable for real-time applications of bio-inspired climbing robot

Auke Ijspeert

Bio-inspired climbing robots relying on adhesion systems are believed to become essential tools for several industrial applications in the near future. In recent years, research has mainly focused on modeling micro-scale adhesion phenomena; a macro-scale a ...

2008

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

Jeffrey Alan Hubbell, Mikaël Martino, Dominique André Rothenfluh, Thomas Barker, Mayumi Mochizuki Martino

The extracellular matrix (ECM) exerts powerful control over many cellular phenomena, including stem cell differentiation. As such, design and modulation of ECM analogs to ligate specific integrin is a promising approach to control cellular processes in vit ...

Elsevier2008

Modulation of the metastatic progression of breast cancer with an organometallic ruthenium compound

Paul Joseph Dyson, Gianni Sava

The modulation of the metastatic progression of breast cancer has been evaluated in vitro and in vivo with RAPTA-T, [Ru(η6-toluene)Cl2(PTA)], an organometallic ruthenium compd. In vitro RAPTA-T inhibits some steps of the metastatic process such as the deta ...

2008

Coating hydrophobic surfaces with amphiphilic thioethers to reduce protein adsorption and cell adhesion

Jeffrey Alan Hubbell, Nicola Tirelli

The present invention provides methods and apparatus for coating surfaces with specially designed thioethers and amphiphilic thioethers that reduce protein adsorption and/or cell adhesion. This reduction may be achieved, for example, by controlling the spa ...

2008

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease

Lorène Aeschbach, Patrick Fraering, Hua Li

Gamma-secretase is an unconventional aspartyl protease that processes many type 1 membrane proteins within the lipid bilayer. Because its cleavage of amyloid-beta precursor protein generates the amyloid-beta protein (Abeta) of Alzheimer's disease, partiall ...

Wiley-Blackwell2008

Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds

Andrzej Kulik, Jean-Jacques Meister, Boris Hinz, Kyumin Lee, Philippe Pittet

We have previously shown that the switch from N-cadherin to OB-cadherin expression increases intercellular adhesion between fibroblasts during their transition from a migratory to a fibrogenic phenotype. Using atomic force microscopy we here show that part ...

2008

UV-curable nanoimprint resin with enhanced anti-sticking property

Joo Yeon Kim

This paper reports on a newly developed anti-sticking resin obtained by mixing a fluorine-containing monomer (F- monomer) for UV nanoimprinting lithography (UV-NIL) to reduce the contact adhesion force during the demolding process. The new resin system sho ...

2008

RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells

Nikolaos Stergiopoulos, Harm-Anton Klok, Paolo Silacci, Stefano Tugulu

This report demonstrates the feasibility of surface-initiated atom transfer radical polymerization to prepare thin polymer layers ("brushes") that can be functionalized with short peptide ligands and which may be of use as coatings to promote endothelializ ...

2007

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