Concept

Norgestimate

Related publications (11)

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

Role of the androgen receptor in the human breast epithelium

Fabio De Martino

Breast cancer is the most common malignancy in women worldwide and understanding the risk factors affecting it is key for prevention. The relative risk of developing breast cancer is related to exposure to both endogenous hormones and exogenous natural and ...

EPFL2022

A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

Cathrin Brisken, Jonathan Paz Montoya, Marc Moniatte, Fabio De Martino, Marie Shamseddin, Csaba Ferenc László, Alexandre Béguin

In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins bestows a breast cancer relative ri ...

2019

Progestins used for hormonal contraception in Switzerland: study of their effects on the breast epithelium

Marie Shamseddin

Breast cancer is the most commonly diagnosed cancer and the most common cause of cancer death among women. Hormones have been shown to have a key role in breast development and carcinogenesis. Repeated activation of progesterone receptor (PR) signaling as ...

EPFL2018

Living-Engineered Valves for Transcatheter Venous Valve Repair

Peter Modregger, Marco Stampanoni

Background: Chronic venous insufficiency (CVI) represents a major global health problem with increasing prevalence and morbidity. CVI is due to an incompetence of the venous valves, which causes venous reflux and distal venous hypertension. Several studies ...

2014

Methodology to account for uncertainties and tradeoffs in pharmaceutical environmental hazard assessment

David Andrew Barry, Luca Rossi, Sylvain Coutu

Many pharmaceutical products find their way into receiving waters, giving rise to concerns regarding their environmental impact. A procedure was proposed that enables ranking of the hazard to aquatic species and human health due to such products. In the pr ...

Elsevier2012

Simulating the fine and coarse inorganic particulate matter concentrations in a polluted megacity

Athanasios Nenes, Spyros Pandis

A three dimensional chemical transport model (PMCAMx) is applied to the Mexico City Metropolitan Area (MCMA) in order to simulate the chemical composition and mass of the major PM1 (fine) and PM1-10 (coarse) inorganic components and determine the effect of ...

2010

Lecithin:cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates

Johan Auwerx

Plasma lipoprotein metabolism is influenced by several factors that may act by regulating the expression of proteins involved in lipoprotein metabolism, such as lecithin:cholesterol acyltransferase (LCAT). We determined the influence of several hormones an ...

1992

Enzymic reaction in a three-phase liquid-liquid-solid catalyst system. Application to the optical resolution of phenylalanine

Albert Renken, Simon Crelier

The development of a phasic system for the enzymic resoln. of racemic phenylalanine (I) up to benchtop pilot plant scale is described. The principle is based upon the hydrolysis of racemic Pr ester of I with immobilized a-chymotrypsin (II) in which only th ...

1991

Transesterification of phenylalanine by means of chymotrypsin in a continuous fixed bed reactor

Albert Renken

An enzymic transesterification was carried out in a continuously operated fixed bed reactor. The reaction system consisted of immobilized a-chymotrypsin catalyzing the transfer of the L-phenylalanine radical from the racemic Pr ester to 1,4-butanediol, yie ...

1991

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