Concept

Proteolysis

Related publications (160)

Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease

Alzheimer's disease is the most common form of neurodegenerative diseases in humans, characterized by the progressive accumulation and aggregation of amyloid-beta peptides (Abeta) in brain regions subserving memory and cognition. These 39-43 amino acids lo ...

Bentham Science Publishers2007

Subpicosecond near-infrared fluorescence upconversion study of relaxation processes in PbSe quantum dots

Majed Chergui, Frank van Mourik, Andrea Cannizzo, Camilla Bonati

The (sub)-ps relaxation processes in PbSe quantum dots of different sizes were measured by near-IR luminescence upconversion. The early-time spectra are characterized by emission from several low-lying excited states. The direct measurement of the Huang-Rh ...

2007

Diagonal chromatographic selection of cysteinyl peptides modified with benzoquinones

Hubert Girault, Loïc Dayon

The derivatization of cysteine-containing peptides with benzoquinone compounds is rapid, quantitative and specific in acidic media. The conversion of cysteines into hydrophobic benzoquinone-adducted residues in peptides is used here to alter the chromatogr ...

Springer Verlag2007

Switch-peptides: from conformational studies to Alzheimer's disease

Hilal Lashuel, Richard Alan Mimna, Jacques Dubochet, Sonia Dos Santos, Karine Murat, Lydiane Jeanine Saucède, Marie-Stéphanie Camus, Jérémy Bérard

A review. Studies on designed peptides that exhibit high tendencies for medium-induced conformational transitions have recently attracted much attention because structural changes are considered as mol. key processes in degenerative diseases. The exptl. ac ...

2006

Multilayer-Assembled Microchip for Enzyme Immobilization as Reactor Toward Low-Level Protein Identification

Hubert Girault

A microchip reactor has been developed on the basis of a layer-by-layer approach for fast and sensitive digestion of proteins. The resulting peptide analysis has been carried out by matrix-assisted laser desorption ionization timeof- flight mass spectromet ...

2006

Switch-peptides as tool for the study of fibrillogenesis

The invention discloses a method for the manuf. of a peptidic folding precursor (switch-peptide) stable and sol. at physiol. conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is t ...

2006

Formation of Microcapsules from Polyelectrolyte and Covalent Interactions

Urs von Stockar, Ian William Marison, Véronique Breguet, Raphaël Gugerli, Mimma Pernetti

A new approach combining electrostatic and covalent bonds was established for the formation of resistant capsules with long-term stability under physiol. conditions. Three kinds of interactions were generated in the same membrane: (1) electrostatic bonds b ...

2005

Switch-peptides: controlling biological function and self-assembly of amyloid ß-derived peptides using enzyme-triggered acyl migrations

Sonia Dos Santos

Conformational transitions of peptides and proteins have recently moved to the center of interest in various domains of research at the interface of chemistry, biology, and medicine due to their implication in an increasing number of diseases in which the ...

EPFL2005

Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism

Melody Swartz, Federica Boschetti, Mark Fleury

Cell organization is largely orchestrated by extracellular gradients of morphogenetic proteins. VEGF, an essential factor for capillary formation, is stored in the extracellular matrix, but the mechanisms by which it and other matrix-bound morphogens are m ...

2005

Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation

Hilal Lashuel

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with clinical manifestations appearing in old age, however, the initial stages of this disease may begin early in life. AD is characterized by the presence of excessive deposits of aggreg ...

Federation of American Society of Experimental Biology2005

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