Concept
Ulcer (dermatology)
Related publications (14)
Prototyping and Experimental Analysis of Active Offloading Footwear for Patients With Diabetes Using an Array of Magnetorheological Fluid–Based Modules
Yves Perriard, Yoan René Cyrille Civet, Paolo Germano, Bhawnath Tiwari
Diabetic foot ulceration is a serious challenge worldwide which imposes an immense risk of lower extremity amputation and in many cases may lead to the death. The presented work focuses on the offloading requirements using an active approach and considers ...
2024A Tunable Self-Offloading Module for Plantar Pressure Regulation in Diabetic Patients
Yves Perriard, Yoan René Cyrille Civet, Paolo Germano, Christian Köchli, Sofia Lydia Ntella, Kenny Jeanmonod, Bhawnath Tiwari
Plantar pressure plays a crucial role in the pathogenesis of foot ulcers among patients with diabetes and peripheral polyneuropathy. Pressure relief is a key requirement for both the prevention and treatment of plantar ulcers. Conventional medical practice ...
2024Intelligent plantar pressure offloading for the prevention of diabetic foot ulcers and amputations
Yves Perriard, Yoan René Cyrille Civet, Christian Köchli, Sofia Lydia Ntella, Kenny Jeanmonod, Bhawnath Tiwari
The high prevalence of lower extremity ulceration and amputation in people with diabetes is strongly linked to difficulties in achieving and maintaining a reduction of high plantar pressures (PPs) which remains an important risk factor. The effectiveness o ...
2023Pressure Offloading Device for Diabetic Footwear Based on Magnetorheological Fluids
Yves Perriard, Yoan René Cyrille Civet, Christian Köchli, Sofia Lydia Ntella, Kenny Jeanmonod
Diabetes is a rapidly growing disease, with important complications that decrease the quality of life of patients. Diabetic Foot Ulceration is a major complication of diabetes and can lead to gangrene and amputation. It is related to high pressure develope ...
IEEE2022Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes
Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, prolifera ...
2019Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling
Jeffrey Alan Hubbell, Melody Swartz, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Manuel Andreas Fankhauser
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growt ...
2017Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles
Prostate cancer (PCa) is one of the leading causes of death among men. Low-dose brachytherapy is an increasingly used treatment for PCa, which requires the implantation of tens of radioactive seeds. This treatment causes discomfort; these implants cannot b ...
Wiley2017Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection
Johan Auwerx, Tytti Heinonen, Marc Pfefferlé
Sirtuin 2 (SIRT2) is one of the seven members of the family of NAD(+)-dependent histone deacetylases. Sirtuins target histones and non-histone proteins according to their subcellular localization, influencing various biological processes. SIRT2 resides mai ...
Frontiers Media Sa2017Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair
Duncan-Bruce Sutherland, Nicola Harris, Benjamin John Marsland, Beatrice Volpe, Julia Esser-von Bieren, Jérôme Bürgi
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses ...
Public Library Science2015Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix
Matthias Lütolf, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Adrian Ranga
By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...
National Academy of Sciences2013