Concept
Punctuated equilibrium
Related publications (10)
Milestones in tumor vascularization and its therapeutic targeting
Michele De Palma, Douglas Hanahan
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising thera ...
Nature Portfolio2024Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction
Qian Wang, Jieping Zhu, Rémi Julien Sylvain Andres
A five-step total synthesis of arborisidine, a caged pentacyclic monoterpene indole alkaloid, has been accomplished in both racemic and enantioselective manners. The synthesis features the following three key steps: (a) a regioselective Pictet-Spengler rea ...
AMER CHEMICAL SOC2020Detecting and Quantifying Changing Selection Intensities from Time-Sampled Polymorphism Data
Jeffrey David Jensen, Matthieu Foll, Sebastian Matuszewski, Stefan Jean Laurent, Hyunjin Shim
During his well-known debate with Fisher regarding the phenotypic dataset of Panaxia dominula, Wright suggested fluctuating selection as a potential explanation for the observed change in allele frequencies. This model has since been invoked in a number of ...
Genetics Society of America2016Identification of Multiphase Reaction Systems with Instantaneous Equilibria
Dominique Bonvin, Julien Léo Billeter, Sriniketh Srinivasan
The identification of kinetic models for multiphase reaction systems is complex due to the simultaneous effect of chemical reactions and mass transfers. The extentbased incremental approach simplifies the modeling task by transforming the reaction system i ...
American Chemical Society2016Parameter Learning in General Equilibrium: The Asset Pricing Implications
Parameter learning strongly amplifies the impact of macroeconomic shocks on marginal utility when the representative agent has a preference for early resolution of uncertainty. This occurs as rational belief updating generates subjective long-run consumpti ...
American Economic Association2016Adaptation decisions and damage costs under uncertainty in an empirical general equilibrium framework
Philippe Thalmann, Frank Vöhringer, Takafumi Usui
Mitigation measures are a priority to avoid irreversible damages to the environment due to climate change. However, additional adaptation efforts will be required to reduce the adverse impacts of projected climate change. While mitigation is more likely to ...
2015Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons
The discovery of alpha-synuclein (a-syn) as the main component of Lewy Bodies (LBs), the pathological hallmarks of Parkinson's disease (PD), and the identification of mutations in the gene coding for a-syn in familial form of PD have reinforced the central ...
EPFL2014Parameter Learning in General Equilibrium: The Asset Pricing Implications
Parameter learning strongly amplifies the impact of macro shocks on marginal utility when the representative agent has a preference for early resolution of uncertainty. This occurs as rational belief updating generates subjective long-run consumption risks ...
Columbia Business School2012