Publications associées à Équilibre ponctué

Asymmetric Total Synthesis of (-)-Arborisidine and (-)-19-epi-Arborisidine Enabled by a Catalytic Enantioselective Pictet-Spengler Reaction

Qian Wang, Jieping Zhu, Rémi Julien Sylvain Andres

A five-step total synthesis of arborisidine, a caged pentacyclic monoterpene indole alkaloid, has been accomplished in both racemic and enantioselective manners. The synthesis features the following three key steps: (a) a regioselective Pictet-Spengler rea ...

AMER CHEMICAL SOC2020

Big Data of the Past

Frédéric Kaplan, Isabella Di Lenardo

Big Data is not a new phenomenon. History is punctuated by regimes of data acceleration, characterized by feelings of information overload accompanied by periods of social transformation and the invention of new technologies. During these moments, private ...

2017

Detecting and Quantifying Changing Selection Intensities from Time-Sampled Polymorphism Data

Jeffrey David Jensen, Matthieu Foll, Sebastian Matuszewski, Hyunjin Shim, Stefan Jean Laurent

During his well-known debate with Fisher regarding the phenotypic dataset of Panaxia dominula, Wright suggested fluctuating selection as a potential explanation for the observed change in allele frequencies. This model has since been invoked in a number of ...

Genetics Society of America2016

Identification of Multiphase Reaction Systems with Instantaneous Equilibria

Dominique Bonvin, Julien Léo Billeter, Sriniketh Srinivasan

The identification of kinetic models for multiphase reaction systems is complex due to the simultaneous effect of chemical reactions and mass transfers. The extentbased incremental approach simplifies the modeling task by transforming the reaction system i ...

American Chemical Society2016

Parameter Learning in General Equilibrium: The Asset Pricing Implications

Pierre Collin Dufresne

Parameter learning strongly amplifies the impact of macroeconomic shocks on marginal utility when the representative agent has a preference for early resolution of uncertainty. This occurs as rational belief updating generates subjective long-run consumpti ...

American Economic Association2016

Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

Carole Desobry

The discovery of alpha-synuclein (a-syn) as the main component of Lewy Bodies (LBs), the pathological hallmarks of Parkinson's disease (PD), and the identification of mutations in the gene coding for a-syn in familial form of PD have reinforced the central ...

EPFL2014