Publications related to Nucleic acid tertiary structure

Enhanced Groove Geometry for Herringbone Grooved Journal Bearings

Although gas-lubricated herringbone grooved journal bearings (HGJB) are known for high rotordynamic stability thresholds, small clearance to diameter ratios are required for stable rotor operation. Tight clearances not only increase bearing losses but also ...

Asme2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Joachim Lingner, Sophie Redon, Ivo Zemp

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...

Oxford University Press2013

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Larissa Grolimund

Telomeres protect linear ends of eukaryotic chromosomes by preventing chromosomal end-to-end fusions and telomere attrition. They consist of repetitive DNA sequences, telomeric repeat containing RNAs (TERRAs) and proteins. Telomeres play a crucial role in ...

EPFL2013

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

Joachim Lingner

Telomerase is responsible for the immortal phenotype of cancer cells and telomerase inhibition may specifically target cancer cell proliferation. Ligands able to selectively bind to G-quadruplex telomeric DNA have been considered as telomerase inhibitors b ...

2012

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

Ursula Röthlisberger, Hilal Lashuel, Florence Pojer, Bruno Claude Daniel Fauvet, Michele Cascella, Marilisa Neri, Magdalena Zweckstetter, Hajer Ouertatani-Sakouhi, Farah El Turk, Min Kyu Cho, Amer Ashrafi

Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically trimer f ...

Public Library of Science2012

A weakly nonlinear mechanism for mode selection in swirling jets

François Gallaire, Philippe Meliga

Global linear and nonlinear bifurcation analysis is used to revisit the spiral vortex breakdown of nominally axisymmetric swirling jets. For the parameters considered herein, stability analyses single out two unstable linear modes of azimuthal wavenumber m ...

Cambridge University Press2012

Molecular Modeling of Bacterial Nanomachineries

Matteo Thomas Degiacomi

Proteins have the ability to assemble in multimeric states to perform their specific biological function. Unfortunately, characterizing experimentally these structures at atomistic resolution is usually difficult. For this reason, in silico methodologies a ...

EPFL2012

Two-dimensional cantilever array with varying spring constants and tip radii for life-science applications

Nico de Rooij, Terunobu Akiyama, Sebastian Gautsch, Peter Vettiger, Frédéric Loizeau, André Meister

A fabrication process for realising two-dimensional cantilever arrays for parallel force spectroscopy of biological samples is presented. The parallel optical atomic force microscopy readout system has been developed and presented elsewhere. The arrays are ...

2012

Bifurcated Helical Core Equilibrium States in Tokamaks

Olivier Sauter, Basil Duval, Stefano Coda, Jonathan Graves, Wilfred Anthony Cooper, Holger Reimerdes, Benoît Labit, Antoine Pochelon, David Pfefferlé, Federico David Halpern, Daniele Brunetti, Jonathan Rossel, Mattia Albergante

Tokamaks with weak to moderate reversed central shear in which the minimum rotational transform

q_{min}

is in the neighbourhood of unity can trigger bifurcated MagnetoHydrodynamic (MHD) equilibrium states, one of which is similar to a saturated ideal ...

2012

On the role of the scanning line density on the etching of fused silica specimens exposed to femtosecond lasers pulses

Yves Bellouard

Fused silica (a-SiO 2) exposure to low-energy femtosecond laser pulses (below ablation threshold) introduces a local increase of the HF etching rate. This property has been used to fabricate a variety of structures ranging from simple fluidic channels to m ...

IEEE2012

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Enhanced Groove Geometry for Herringbone Grooved Journal Bearings

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

A weakly nonlinear mechanism for mode selection in swirling jets

Molecular Modeling of Bacterial Nanomachineries

Two-dimensional cantilever array with varying spring constants and tip radii for life-science applications

Bifurcated Helical Core Equilibrium States in Tokamaks

On the role of the scanning line density on the etching of fused silica specimens exposed to femtosecond lasers pulses

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Specific binding of telomeric G-quadruplexes by hydrosoluble perylene derivatives inhibits repeat addition processivity of human telomerase

On the role of the scanning line density on the etching of fused silica specimens exposed to femtosecond lasers pulses

A weakly nonlinear mechanism for mode selection in swirling jets

Molecular Modeling of Bacterial Nanomachineries

Two-dimensional cantilever array with varying spring constants and tip radii for life-science applications

Enhanced Groove Geometry for Herringbone Grooved Journal Bearings

Bifurcated Helical Core Equilibrium States in Tokamaks

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket