Concept

Merkel-cell carcinoma

Related publications (42)

Chronic wound healing by fetal cell therapy may be explained by differential gene profiling observed in fetal versus old skin cells

Dominique Pioletti, Corinne Scaletta, Nathalie Hirt-Burri

Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can ...

2009

Comparison of ALA- and ALA hexyl-ester-induced PpIX depth distribution in human skin carcinoma

Hubert van den Bergh, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tanja Gabrecht

Photodynamic therapy (PDT) based on the use of photoactivable porphyrins, such as protoporphyrin IX (PpIX), induced by the topical application of amino-levulinic acid (ALA) or its derivatives, ALA methyl-ester (m-ALA), is a treatment for superficial basal ...

Elsevier2008

Ruthenium Porphyrin Compounds for Photodynamic Therapy of Cancer

Paul Joseph Dyson, Wee Han Ang, Frédéric Schmitt

Five 5,10,15,20-tetra(4-pyridyl)porphyrin (TPP) areneruthenium(II) derivs., a p-cymeneosmium, a pentamethylcyclopentadienyliridium and a pentamethylcyclopentadienylrhodium analog were prepd. and characterized as potential photosensitizing chemotherapeutic ...

2008

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling

Ilaria Malanchi, Deepika Kassen

Continuous turnover of epithelia is ensured by the extensive self-renewal capacity of tissue-specific stem cells. Similarly, epithelial tumour maintenance relies on cancer stem cells (CSCs), which co-opt stem cell properties. For most tumours, the cellular ...

2008

Reduction of brain metastases in plasminogen activator inhibitor-1 deficient mice with transgenic ocular tumors

Friedrich Beermann

Plasminogen activator inhibitor-1 is known to play a paradoxical positive role in tumor angiogenesis, but its contribution to metastatic spread remains unclear. We studied the impact of PAI-1 deficiency in a transgenic mouse model of ocular tumors originat ...

Oxford University Press2008

The fibroblast growth factor-2 is not essential for melanoma formation in a transgenic mouse model

Friedrich Beermann

Fibroblast growth factor 2 (FGF2) has been assigned a role in melanocyte proliferation and in development of human cutaneous melanoma. We have used a transgenic mouse melanoma model in combination with mice lacking mouse FGF2 to analyse the possible implic ...

2005

Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background

Manon Frutschi, Friedrich Beermann

In human cutaneous malignant melanoma, a predominance of activated mutations in the N-ras gene has been documented. To obtain a mouse model most closely mimicking the human disease, a transgenic mouse line was generated by targeting expression of dominant- ...

2005

Imaging cells and tissues with refractive index radiology

Giorgio Margaritondo, Amela Groso, Yong Yang

Can individual cells, including live cells, be imaged using hard x rays? Common wisdom until now required sophisticated staining techniques for this task. We show instead that individual cells and cell details can be detected in culture solution and tissue ...

2004

Optimalisation de la photothérapie dynamique et de la photodétection de cancers précoces par spectroscopie résolue en temps de luminophores endogènes et exogènes

Pascal Uehlinger

The aim of this thesis is to optimize and obtain fundamental information on i) the photodetection (PD) of early stage cancers in the tracheo-bronchial tree by spectroscopic imaging of the tissue autofluorescence, ii) photodynamic therapy (PDT) applied in d ...

EPFL2004

Notch1 functions as a tumor suppressor in mouse skin

Freddy Radtke

Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is associated with tumorigenesis. The role of Notch signaling in mammalian skin is less well characterized ...

2003

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