Concept

Intrinsically photosensitive retinal ganglion cell

Related publications (154)

Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy

Retinal gene therapy could potentially affect the lives of millions of people suffering from blinding disorders. Yet, one of the major hurdles remains the delivery of therapeutic nucleic acids to the retinal target cells. Due to the different barriers that ...

Elsevier2015

Gene therapy and bioengineering for retinal diseases: what is the future?

Diego Ghezzi

Sight restoration after retinal degeneration still represents an unmet goal. Since therapeutic strategies increasingly require interdisciplinary competencies, photoreceptor degeneration is attracting several research areas, including: life science, materia ...

2015

Differential Dimerization of Variants Linked to Enhanced S-Cone Sensitivity Syndrome (ESCS) Located in the NR2E3 Ligand-Binding Domain

Nicolas Jean Philippe Guex, Pascal Escher

NR2E3 encodes the photoreceptor-specific nuclear hormone receptor that acts as a repressor of cone-specific gene expression in rod photoreceptors, and as an activator of several rod-specific genes. Recessive variants located in the ligand-binding domain (L ...

Wiley-Blackwell2015

A framework for predicting the non-visual effects of daylight – Part II: The simulation model

Marilyne Andersen, Nicolas Roy

This paper describes a climate-based simulation framework devised to investigate the potential for the non-visual effects of daylight in buildings. It is part 2 of a study where the first paper focused on the formulation of the photobiological underpinning ...

SAGE Publications2014

A polymer-based interface restores light sensitivity in blind rats

Diego Ghezzi

Progressive degeneration of photoreceptors is one of the major causes of adult blindness in “industrialized” countries; as an example, Retinitis pigmentosa defines a set of monogenic hereditary retinal diseases, with a prevalence of 1:4000 worldwide, cause ...

2014

A polymer-based interface restores light sensitivity in blind rats

Diego Ghezzi

Purpose: Sight restoration is one of the new frontiers for prosthetic devices that enable the electrical stimulation of neurons. In particular, diseases affecting the retinal pigment epithelium and photoreceptors but preserve the inner retinal layers are p ...

2014

Novel ADAM9 homozygous mutation in a consanguineous Egyptian family with severe cone-rod dystrophy and cataract

Tatiana Favez

Objective To genetically and phenotypically describe a new ADAM9 homozygous mutation in a consanguineous family from Egypt with autosomal recessive cone-rod dystrophy (arCRD), anterior polar and posterior subcapsular cataract. Design, setting and participa ...

Bmj Publishing Group2014

High throughput second harmonic imaging for label-free biological applications

Pierre Magistretti, Sylvie Roke, Aleksandra Radenovic, Carlos Alberto Macias Romero, Orly Bagunu Tarun, Pierre Marquet, Pascal Jourdain, Vitalijs Zubkovs, Marie Eve Pascale Didier

Second harmonic generation (SHG) is inherently sensitive to the absence of spatial centrosymmetry, which can render it intrinsically sensitive to interfacial processes, chemical changes and electrochemical responses. Here, we seek to improve the imaging th ...

Optical Society of America2014

Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver

Felix Naef, Frédéric Bruno Martin Gachon, Daniel Alain Dominique Marie Mauvoisin, Jingkui Wang, Florian Atger, Celine Jouffe

Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known ab ...

Natl Acad Sciences2014

Intrinsically photosensitive retinal ganglion cells: classification, function and clinical implications

Purpose of review The discovery of a new class of intrinsically photosensitive retinal ganglion cells (ipRGCs) revealed their superior role for various nonvisual biological functions, including the pupil light reflex, and circadian photoentrainment. Recent ...

Lippincott, Williams & Wilkins2013

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