Concept

Brain metastasis

Related publications (95)

Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells

Aim: Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO-NPs) are under development for imaging and drug delivery; however, their interaction with human blood brain barrier models is not known. Materials & Methods: The uptake, reactive oxygen spec ...

2012

High-performance and site-directed in utero electroporation by a triple-electrode probe

Diego Ghezzi

In utero electroporation is a powerful tool to transfect and manipulate neural-precursor cells of the rodent parietal cortex and their progeny in vivo. Although this technique can potentially target numerous brain areas, reliability of transfection in some ...

2012

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Friedrich Beermann, Ang Li

Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ...

2011

Histogram Analysis of the Microvasculature of Intracerebral Human and Murine Glioma Xenografts

Nathalie Just

The purpose of this study is to examine the usefulness of histogram analysis combined with vessel size index (VSI) magnetic resonance imaging for the specific characterization of brain tumor microvasculature in a panel of six volume-matched glioma xenograf ...

Wiley-Blackwell2011

Radiation-induced modifications of the tumor microenvironment promote metastasis

Natsuko Imaizumi

Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor ...

2011

Multiscale modeling of lymphatic drainage from tissues using homogenization theory

Melody Swartz

Lymphatic capillary drainage of interstitial fluid under both steady-state and inflammatory conditions is important for tissue fluid balance, cancer metastasis, and immunity. Lymphatic drainage function is critically coupled to the fluid mechanical propert ...

Elsevier2011

High intensity focused ultrasound for transcranial therapy of brain lesions and disorders

Yves Martin, Najat Salameh, Benjamin Robert

A novel MR-guided brain therapy device operating at 1 MHz has been designed and constructed. The system has been installed and tested in a clinical 1.5 T Philips Achieva MRI. Skull bone distortions induced on the ultrasonic beam are corrected using the con ...

2010

Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

Melody Swartz, Amanda Waite Lund

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, ...

Springer Verlag2010

Lymphatic Biodistribution of Polylactide Nanoparticles

Li Tang

Tumor metastases occur through both the cardiovascular and lymphatic circulations. However, the majority of nanoparticle biodistribution studies have been focused on the cardiovascular circulation. In this study, we report the formulation of Cy5-labeled po ...

2010

Next-Generation Anticancer Metallodrugs

Angela Casini

More than 99% of currently approved clinical drugs are organic compounds. In contrast, the percentage of metal-containing drugs (metallodrugs) is very low. In cancer chemotherapy, however, platinum coordination compounds represented by cisplatin and deriva ...

2010

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