Peri-implantitis

Applied sciences
Chemical engineering
Materials science
Biomaterials science

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Osteoclastogenesis can be mechanically-induced in the peri-implant bone

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Total joint replacements are highly successful in relieving pain and restoring movement of damaged joints. However, the lifespan of the implants is limited. The implant’s long-term stability depends largely on the preservation of periprosthetic bone. Debri ...

2009

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

Bone reactions to controlled loading of endosseous implants: a pilot study

John Botsis, Joël Cugnoni

Objectives: To validate an experimental setup designed to apply load onto bone tissue using osseointegrated implants in a rabbit model. Specifically, (1) to design an apparatus capable of generating controlled forces, (2) to assess implant placement, maint ...

Wiley-Blackwell2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

A composite biofoam, from research to in vivo validation

Dominique Pioletti, Pierre-Etienne Bourban

Bone tissue engineering aims at developing scaffolds, or porous structures, as supports for cell migration, proliferation and differentiation, in order to favor bone healing. L-poly lactic acid (PLA) foams, which were reinforced or not with β-tricalcium ph ...

2007

Bone-cement interface of the glenoid component: stress analysis for varying cement thickness

Alexandre Terrier, Alain Farron, Philippe Büchler

BACKGROUND: Although shoulder arthroplasty is an accepted treatment for osteoarthritis, loosening of the glenoid component, which mainly occurs at the bone-cement interface, remains a major concern. Presently, the mechanical effect of the cement mantel thi ...

2005

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Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

2008

Bone reactions to controlled loading of endosseous implants: a pilot study

John Botsis, Joël Cugnoni

Wiley-Blackwell2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

2008