Concept

Metabolic network

Related publications (222)

Accumulation of pollutants and plant wellness: bottleneck or key to a successful phytoremediation?

Plants have efficient mechanisms for detoxification and sequestration of xenobiotic chemicals and trace elements, basis of any efficient phytoremediation process. However the amount of pollutants that can be accumulated and detoxified without disrupting th ...

2012

Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

Johan Auwerx, Richardus Houtkooper, Cyril Mikhail

Although sleep is defined as a behavioral state, at the cortical level sleep has local and use-dependent features suggesting that it is a property of neuronal assemblies requiring sleep in function of the activation experienced during prior wakefulness. He ...

Soc Neuroscience2012

Utilization of NMR spectroscopy to study biological fluids and metabolic processes: Two introductory activities

Luciano Andres Abriata

This work describes two activities designed to introduce students into the use of NMR spectroscopy for the analysis of biological fluids. In the first activity, 1H spectra of common beverages are acquired and analyzed to identify their most abundant consti ...

Wiley-Blackwell2012

Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD(+)?

Johan Auwerx, Carlos Canto Alvarez

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD(+)-dependent deacetylase that is at the pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in intracellular NAD(+) levels, which reflect energy level, and uses this inf ...

2012

Physiological adaptation of Desulfitobacterium hafniense strain TCE1 to tetrachloroethene respiration

Christof Holliger, Julien Maillard, Laure Prat

Desulfitobacterium spp. are ubiquitous organisms with a broad metabolic versatility and some isolates have the ability to use tetrachloroethene (PCE) as terminal electron acceptor. In order to identify proteins involved in this organohalide respiration pro ...

American Society for Microbiology2011

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Heinrich Hofmann

Background: Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal ...

2011

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

Pierre Magistretti, Igor Allaman

The energy requirements of the brain are very high, and tight regulatory mechanisms operate to ensure adequate spatial and temporal delivery of energy substrates in register with neuronal activity. Astrocytes a type of glial cell have emerged as active pla ...

2011

The response of Desulfotomaculum reducens MI-1 to U(VI) exposure: a transcriptomic study

Rizlan Bernier-Latmani, Elena Cristina Dalla Vecchia

Desulfotomaculum reducens is the first Gram-positive sulfate- and metal-reducing bacterium for which the transcriptomic response to uranium exposure has been evaluated. The genes upregulated during fermentative growth in the presence of U(VI) as compared t ...

Taylor & Francis2011

E2F transcription factor-1 regulates oxidative metabolism

Johan Auwerx

Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic ...

2011

Semisynthesis of fluorescent metabolite sensors on cell surfaces

Horst Vogel, Kai Johnsson, Luc Reymond, Rudolf Griss, Joachim Piguet, Matthias Albert Brun, Kui Thong Tan, Ruud Peters

Progress in understanding signal transduction and metabolic pathways is hampered by a shortage of suitable sensors for tracking metabolites, second messengers, and neurotransmitters in living cells. Here we introduce a class of rationally designed semisynt ...

2011

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