Concept

Personalized medicine

Related publications (125)

Label-Free Detection of Tobramycin in Serum by Transmission-Localized Surface Plasmon Resonance

Carlotta Guiducci, Thierry Buclin, Anna Ferretti, Giulia Cappi, Fabio Mario Spiga, Laurent Décosterd, Michael Beyeler

In order to improve the efficacy and safety of treatments, drug dosage needs to be adjusted to the actual needs of each patient in a truly personalized medicine approach. Key for widespread dosage adjustment is the availability of point-of-care devices abl ...

Amer Chemical Soc2015

Quantification of low molecular weight drugs

Anna Ferretti

Therapeutic Drug Monitoring (TDM) is considered one of the most successful approaches to personalized medicine. However, the accuracy requirements on the quantification of drug concentration and the challenges in the dose adjustment limit the application o ...

EPFL2015

From cardiac tissue engineering to heart-on-a-chip: beating challenges

Francesco Piraino

The heart is one of the most vital organs in the human body, which actively pumps the blood through the vascular network to supply nutrients to as well as to extract wastes from all other organs, maintaining the homeostasis of the biological system. Over t ...

Iop Publishing Ltd2015

The Convergence of Systems and Reductionist Approaches in Complex Trait Analysis

Johan Auwerx, Evan Graehl Williams

Research into the genetic and environmental factors behind complex trait variation has traditionally been segregated into distinct scientific camps. The reductionist approach aims to decrypt phenotypic variability bit by bit, founded on the underlying hypo ...

2015

Integrated Electronics to Control and Readout Electrochemical Biosensors for Implantable Applications

Seyedeh Sara Ghoreishizadeh

Biosensors can effectively be used to monitor multiple metabolites such as glucose, lactate, ATP and drugs in the human body. Continuous monitoring of these metabolites is essential for patients with chronic or critical conditions. Moreover, this can be us ...

EPFL2015

Nanosensors for early cancer detection and for therapeutic drug monitoring

Francesco Stellacci

The use of nanotechnology for drug delivery in cancer therapy has raised high expectations. Additionally, the use of nanomaterials in sensors to extract and detect tumor specific biomarkers, circulating tumor cells, or extracellular vesicles shed by the tu ...

Future Medicine2015

[Genomic medicine and infectious diseases]

Jacques Fellay

Relentless progress in our knowledge of the nature and functional consequences of human genetic variation allows for a better understanding of the protracted battle between pathogens and their human hosts. Multiple polymorphisms have been identified that i ...

2014

Médecine génomique et Maladies infectieuses [Genomic medicine and infectious diseases]

Jacques Fellay

Les progrès actuels dans la connaissance des variations génétiques humaines et de leurs conséquences fonctionnelles permettent de mieux comprendre la bataille millénaire que se livrent l'homme et les microbes. De nombreux polymorphismes modulant notre répo ...

2014

HLA class I and KIR genes do not protect against HIV type 1 infection in highly exposed uninfected individuals with hemophilia A

Jacques Fellay

A recent genome-wide association study (GWAS) involving patients with hemophilia A who were exposed to but uninfected with human immunodeficiency virus type 1 (HIV-1) did not reveal genetic variants associated with resistance to HIV-1 infection, beyond hom ...

Oxford University Press2014

Patient Privacy in the Genomic Era

Jean-Pierre Hubaux, Erman Ayday, Jean Louis Raisaro

According to many scientists and clinicians, genomics is taking on a key role in the field of medicine. Impressive advances in genome sequencing have opened the way to a variety of revolutionary applications in modern healthcare. In particular, the increas ...

2014

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