Concept

Personalized medicine

Related publications (125)

Probing chemical structures and physical processes with nanopores

This thesis develops and applies the nanopore tool to probe chemical structures and physical processes at the single-molecule level: from single ions to DNA molecules. Nanopore experiments electrically measure the ionic transport through the pore and its m ...

EPFL2016

Transmission of drug-resistant leprosy in Guinea-Conakry detected by molecular epidemiological approaches

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Chloé Marie Loiseau

Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transm ...

Oxford Univ Press Inc2016

Implantable Multi-panel Platform for Continuous Monitoring of Exogenous and Endogenous Metabolites for Applications in Personalized Medicine

Camilla Baj-Rossi

Nowadays, scientific advances are leading to the discovery of newer, better, more targeted treatments that will improve the human health. However, despite the promising results and the major advantages in treatments offered to patients, these personalized ...

EPFL2015

Quantifying Genomic Privacy via Inference Attack with High-Order SNV Correlations

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday, Zhicong Huang, Sahel Shariati Samani

As genomic data becomes widely used, the problem of genomic data privacy becomes a hot interdisciplinary research topic among geneticists, bioinformaticians and security and privacy experts. Practical attacks have been identified on genomic data, and thus ...

2015

Full System for Translational Studies of Personalized Medicine with Free-Moving Mice (invited)

Giovanni De Micheli, Sandro Carrara, Catherine Dehollain, Francesca Stradolini, Cristina Boero, Camilla Baj-Rossi, Seyedeh Sara Ghoreishizadeh, Enver Gürhan Kilinç, Grégoire Casimir Joseph Surrel, Stefano Riario

A full remotely powered system for metabolism monitoring of free-moving mice is presented here. The fully implantable sensing platform hosts two ASICs, one off-the-shelf micro-controller, four biosensors, two other sensors, a coil to receive power, and an ...

2015

Privacy in the Genomic Era

Jean-Pierre Hubaux, Jacques Fellay, Erman Ayday

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highlydetailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including personalized medical ...

Assoc Computing Machinery2015

Privacy Threats and Practical Solutions for Genetic Risk Tests

Jean-Pierre Hubaux, Erman Ayday, Jean Louis Raisaro, Ludovic Barman, Mohammed-Taha El Graini

Recently, several solutions have been proposed to address the complex challenge of protecting individuals’ genetic data during personalized medicine tests. In this short paper, we analyze different privacy threats and propose simple countermeasures for the ...

2015

CNT and proteins for bioelectronics in personalized medicine

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Andrea Cavallini

From their discovery, CNTs have increasingly attracted interest because of their peculiar electrical, mechanical, and chemical properties. In 1991, Sumio Iijima first observed and described in detail the atomic arrangement of this new type of carbon struct ...

Cambridge University Press2015

Colorectal cancer classification with differential prognosis and personalized therapeutic responses

Douglas Hanahan, Anguraj Sadanandam

The present invention relates to gene sets, the expression levels of which are useful for classifying colorectal tumors and predicting disease-free prognosis and response of patients to specific therapies that are either novel or currently available in the ...

2015

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Douglas Hanahan, Anguraj Sadanandam, Stephan Wullschleger, Ismaël Wafy

Seeking to assess the representative and instructive value of an engineered mouse model of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled and compared mRNA and miRNA transcriptomes of tumors from both. Mouse PanNET tumo ...

Amer Assoc Cancer Research2015

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