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How much gene flow is needed to inhibit speciation by the accumulation of Dobzhansky-Muller incompatibilities (DMIs) in a structured population? Here, we derive these limits in a classical migration-selection model with two haploid or diploid loci and unid ...
Face to the increasing demand for energy, the declining availability of fossil fuels and the periodical tensions in the geopolitical context of oil-producing countries have raised serious concerns in the governments worldwide as well as in the public opini ...
It is becoming increasingly clear that mitochondria play an important role in neural function. Recent studies show mitochondrial morphology to be crucial to cellular physiology and synaptic function and a link between mitochondrial defects and neuro-degene ...
Institute of Electrical and Electronics Engineers2012
Cognitive abilities and disorders unique to humans are thought to result from adaptively driven changes in brain transcriptomes, but little is known about the role of cis-regulatory changes affecting transcription start sites (TSS). Here, we mapped in huma ...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of thymocytes affecting preferentially children and adolescents. The disease is heterogeneous and characterized by a large set of chromosomal and genetic alterations that ...
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. The first miRNA was discovered less than 20 years ago in the context of studying Caenorabditis elegans development. The discovery of the second miR ...
The role of humans in the global dispersal of free-living terrestrial microorganisms has received surprisingly little attention in the literature, compared with the frequent discussions of human dispersal for aquatic microbes. Here I argue that this area n ...
Wall-bounded turbulent flows at high Reynolds numbers have become an increasingly active area of research in recent years. Many challenges remain in theory, scaling, physical understanding, experimental techniques, and numerical simulations. In this paper ...
Coupling between electrical and mechanical phenomena is ubiquitous in nature and underpins the functionality of materials and systems as diversified as ferroelectrics and multiferroics to electroactive molecules to biological systems. Recent years have wit ...
Information access in meeting recordings can be assisted by meeting browsers, or can be fully automated following a question-answering (QA) approach. An information access task is defined, aiming at discriminating true vs. false parallel statements about f ...
