Concept

Recent African origin of modern humans

Related publications (34)

Estimating the Topology of Preferential Attachment Graphs Under Partial Observability

This work addresses the problem of learning the topology of a network from the signals emitted by the network nodes. These signals are generated over time through a linear diffusion process, where neighboring nodes exchange messages according to the underl ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2023

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

Konstantin Popadin

The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...

London2023

Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors

Konstantin Popadin

The hypothesis that the evolution of humans involves hybridization between diverged species has been actively debated in recent years. We present the following novel evidence in support of this hypothesis: the analysis of nuclear pseudogenes of mtDNA ("NUM ...

MDPI2022

Computational model of the dorsal horn circuitry for innocuous touch

Silvestro Micera, Simone Romeni

Providing a naturalistic tactile sensory feedback is currently one of the key challenges in neuroprosthetics. Modeling has played a fundamental role in the development of "biomimetic" stimulation protocols, determining optimal activation patterns to be eli ...

IEEE2021

Optimization of MEW instrument components and their assembly

Jianan Mao

In recent years, a new additive manufacturing technology Melt Electrowriting (MEW) has become attractive, especially for biomedical applications, and it has potential in many other fields as well. In order to carry out an in-depth study of melt electrowrit ...

2021

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

Didier Trono, Alberto De Iaco

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TE ...

2020

Ultrafast photoinduced energy and charge transfer

Majed Chergui

After presenting the basic theoretical models of excitation energy transfer and charge transfer, I describe some of the novel experimental methods used to probe them. Finally, I discuss recent results concerning ultrafast energy and charge transfer in biol ...

2019

Gender medicine and oncology: report and consensus of an ESMO workshop

Jacques Fellay

Background: The importance of sex and gender as modulators of disease biology and treatment outcomes is well known in other disciplines of medicine, such as cardiology, but remains an undervalued issue in oncology. Considering the increasing evidence for t ...

OXFORD UNIV PRESS2019

The Demographic History of African Drosophila melanogaster

Jeffrey David Jensen, Adamantia Kapopoulou, Susanne Petra Pfeifer, Stefan Jean Laurent

As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophila melanogaster remains as an important research question. This owes both to the inherent interest in charac ...

OXFORD UNIV PRESS2018

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

Jacques Fellay, Nimisha Chaturvedi

Tuberculosis is an ancient human disease, estimated to have originated and evolved over thousands of years alongside modern human populations. Despite considerable advances in disease control, tuberculosis remains one of the world's deadliest communicable ...

2018

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