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A signature (ˈsɪɡnətʃəɹ; from signare, "to sign") is a handwritten (and often stylized) depiction of someone's name, nickname, or even a simple "X" or other mark that a person writes on documents as a proof of identity and intent. The writer of a signature is a signatory or signer. Similar to a handwritten signature, a signature work describes the work as readily identifying its creator. A signature may be confused with an autograph, which is chiefly an artistic signature. This can lead to confusion when people have both an autograph and signature and as such some people in the public eye keep their signatures private whilst fully publishing their autograph. Function and types The traditional function of a signature is to permanently affix to a document a person's uniquely personal, undeniable self-identification as physical evidence of that person's personal witness and certification of the content of all, or a specified part, of the document. For example, the role of a

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COM-401: Cryptography and security

This course introduces the basics of cryptography. We review several types of cryptographic primitives, when it is safe to use them and how to select the appropriate security parameters. We detail how they work and sketch how they can be implemented.

FIN-413: Financial applications of blockchains and distributed ledgers

This course provides an introduction to distributed ledger technology, blockchains and cryptocurrencies, and their potential applications in finance and banking.

CS-523: Advanced topics on privacy enhancing technologies

This advanced course will provide students with the knowledge to tackle the design of privacy-preserving ICT systems. Students will learn about existing technologies to prect privacy, and how to evaluate the protection they provide.

Electronic mail (email or e-mail) is a method of transmitting and receiving messages using electronic devices. It was conceived in the late–20th century as the digital version of, or counterpart t

Contract

A contract is an agreement that specifies certain legally enforceable rights and obligations pertaining to two or more mutually agreeing parties. A contract typically involves the transfer of goods,

Authentication

Authentication (from αὐθεντικός authentikos, "real, genuine", from αὐθέντης authentes, "author") is the act of proving an assertion, such as the identity of a computer system user. In contrast with i

CL9/9L-beta-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

Michel Aguet, Pascale Anderle Pedone, Sylvie André Baflast, Frédérique Baruthio, Mauro Delorenzi, Andreas Eduard Moor, Patrick Rodriguez, Norbert Wiedemann

BCL9/9L proteins enhance the transcriptional output of the beta-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9/9L-dependent gene signature derived from independent mouse colorectal cancer (CRC) models unprecedentedly separates patient subgroups with regard to progression free and overall survival. We found that this effect was by and large attributable to stemness related gene sets. Remarkably, this signature proved associated with recently described poor prognosis CRC subtypes exhibiting high stemness and/or epithelial-to-mesenchymal transition (EMT) traits. Consistentwith the notion that high WNT signaling is required for stemnessmaintenance, ablating Bcl9/9l-beta-catenin inmurine oncogenic intestinal organoids provoked their differentiation and completely abrogated their tumorigenicity, while not affecting their proliferation. Therapeutic strategies aimed at targetingWNT responses may be limited by intestinal toxicity. Our findings suggest that attenuating WNT signaling to an extent that affects stemness maintenance without disturbing intestinal renewal might be well tolerated and prove sufficient to reduce CRC recurrence and dramatically improve disease outcome. (C) 2015 The Authors. Published by Elsevier B.V.

Elsevier Science Bv2015

Hardware Attacks against Hash-based Cryptographic Algorithms

Aymeric Genet

This thesis surveys the current state of the art of hash-based cryptography with a view to finding vulnerabilities related to side-channel attacks and fault attacks. For side-channel investigation, we analyzed the power consumption of an Arduino Due microcontroller running a custom ARM implementation of SPHINCS-256---the most advanced digital signature scheme based on hash functions. Simple power analysis (SPA) was applied on a single trace to obtain a first insight into the implementation, and then on multiple traces to identify an initial data dependence of the power consumption on the hash functions involved in the instance. Based on this result, differential power analysis (DPA), with difference of means, V-test, and Pearson correlation, was applied to further investigate the leakage relating to BLAKE-256, as this function is used within SPHINCS-256 several times with the same secret key but applied on different known addresses. Concerning fault attacks, using instances of one-time signature (OTS) or few-times signatures (FTS) to sign a same message has been shown to theoretically make many schemes, such as LD-OTS, W-OTS, and HORS, existentially forgeable with non-invasive attacks. These vulnerabilities are fatal for the Merkle signature schemes which implement the tree chaining method (CMSS). When the schemes provide n/2 = 128 bits of quantum security, a universal forgery can be created with around q = 20 different faulty signatures. This thesis demonstrates a practical application of fault attacks to create this universal forgery using voltage glitching on the previously mentioned ARM implementation of SPHINCS-256. An invasive attack performing key recovery against W-OTS by forcing bits of two quantities to be zero is also described. Countermeasures to thwart all the described attacks are discussed.

2017

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

Michel Aguet, Pascale Anderle Pedone, Sylvie André Baflast, Mauro Delorenzi

To better understand the relationship between tumor-host interactions and the efficacy of chemotherapy, we have developed an analytical approach to quantify several biological processes observed in gene expression data sets. We tested the approach on tumor biopsies from individuals with estrogen receptor-negative breast cancer treated with chemotherapy. We report that increased stromal gene expression predicts resistance to preoperative chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC) in subjects in the EORTC 10994/BIG 00-01 trial. The predictive value of the stromal signature was successfully validated in two independent cohorts of subjects who received chemotherapy but not in an untreated control group, indicating that the signature is predictive rather than prognostic. The genes in the signature are expressed in reactive stroma, according to reanalysis of data from microdissected breast tumor samples. These findings identify a previously undescribed resistance mechanism to FEC treatment and suggest that antistromal agents may offer new ways to overcome resistance to chemotherapy.

Nature Publishing Group2009