Publications related to Systemic scleroderma

Inhalation of Microplastics—A Toxicological Complexity

Florian Frédéric Vincent Breider, Myriam Borgatta

Humans are chronically exposed to airborne microplastics (MPs) by inhalation. Various types of polymer particles have been detected in lung samples, which could pose a threat to human health. Inhalation toxicological studies are crucial for assessing the e ...

2024

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Freddy Radtke, Ute Koch, Jialin Zhang, Soufiane Boumahdi

Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined f ...

ELSEVIER2023

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Luc Xavier Marie Lebon

Approximately 2 billion people worldwide and a significant part of the domestic livestock are infected with soil-transmitted helminths, of which many establish chronic infections causing substantial eco-nomic and welfare burdens. Beside intensive research ...

2022

Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

Jacques Fellay, Christian Axel Wandall Thorball, Nicolas Meyer

Objective Primary Sjogren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptom ...

WILEY2022

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Jacques Fellay, Olivier Noël Marie Naret, Flavia Aurelia Shoko Hodel, Clara Bonnet

Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...

BMC2022

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

Bruno Lemaitre, Mark Austin Hanson, Alexia Laurie Carboni

Cecropins are small helical secreted peptides with antimicrobial activity that are widely distributed among insects. Genes encoding Cecropins are strongly induced upon infection, pointing to their role in host defense. In Drosophila, four cecropin genes cl ...

OXFORD UNIV PRESS INC2022

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

Johan Auwerx, Jun Yong Kim, Dongryeol Ryu, Ludger Jan Elzuë Goeminne

Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in r ...

2020

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Systemic scleroderma

Inhalation of Microplastics—A Toxicological Complexity

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice

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Chat with Graph Search

Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

Inhalation of Microplastics—A Toxicological Complexity

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

Variability of Primary Sjogren's Syndrome Is Driven by Interferon alpha and Interferon alpha Blood Levels Are Associated With the Class II HLA-DQ Locus

The combined impact of persistent infections and human genetic variation on C-reactive protein levels

Cecropins contribute to Drosophila host defense against a subset of fungal and Gram-negative bacterial infection

The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy

Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice