Concept
Addiction
Related publications (75)
Unaltered cocaine self-administration in the prenatal LPS rat model of schizophrenia
Although cocaine abuse is up to three times more frequent among schizophrenic patients, it remains unclear why this should be the case and whether sex influences this relationship. Using a maternal immune activation model of schizophrenia, we tested whethe ...
Pergamon-Elsevier Science Ltd2016Methyl Supplementation Attenuates Cocaine-Seeking Behaviors and Cocaine-Induced c-Fos Activation in a DNA Methylation-Dependent Manner
Epigenetic mechanisms, such as histone modifications, regulate responsiveness to drugs of abuse, such as cocaine, but relatively little is known about the regulation of addictive-like behaviors by DNA methylation. To investigate the influence of DNA methyl ...
Soc Neuroscience2015The impact of anxiety and reward-seeking traits on social competition and the role of the mesolimbic dopaminergic system
Social hierarchies are established across a range of different taxa in the animal kingdom. Given that hierarchy inequalities are highly present in nowadays society and the health problems that low rank individuals suffer from this, it is surprising that no ...
EPFL2015Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System
Background: In recent years, deep brain stimulation (DBS) has emerged as a promising treatment option for patients suffering from treatment-resistant depression (TRD). Several stimulation targets have successfully been tested in clinical settings, includin ...
Elsevier Science Inc2015Disrupting astrocyte-neuron lactate transfer persistently reduces conditioned responses to cocaine
Pierre Magistretti, Jean-Luc Martin, Benjamin Boutrel, Benjamin Boury-Jamot, Anthony Carrard
A central problem in the treatment of drug addiction is the high risk of relapse often precipitated by drug-associated cues. The transfer of glycogen-derived lactate from astrocytes to neurons is required for long-term memory. Whereas blockade of drug memo ...
Nature Publishing Group2015Social reward improves the voluntary control over localized brain activity in fMRI-based neurofeedback training
Neurofeedback (NF) based on real-time functional magnetic resonance imaging (rt-fMRI) allows voluntary regulation of the activity in a selected brain region. For the training of this regulation, a well-designed feedback system is required. Social reward ma ...
Frontiers Research Foundation2015TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
Didier Trono, Priscilla Turelli, Adamantia Kapopoulou, Johan Jakobsson
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): ...
Elsevier2015Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)
Friedhelm Christoph Hummel, Simone Rossi
A group of European experts was commissioned to establish guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) from evidence published up until March 2014, regarding pain, movement disorders, stroke, amyotrophic lateral ...
2014