Characene (Ancient Greek: Χαρακηνή), also known as Mesene (Μεσσήνη) or Meshan, was a kingdom founded by the Iranian Hyspaosines located at the head of the Persian Gulf mostly within modern day Iraq. Its capital, Charax Spasinou (Χάραξ Σπασινού), was an important port for trade between Mesopotamia and India, and also provided port facilities for the city of Susa further up the Karun River. The kingdom was frequently a vassal of the Parthian Empire. Characene was mainly populated by Arabs, who spoke Aramaic as their cultural language. All rulers of the principality had Iranian names. Members of the Arsacid dynasty also ruled the state. The name "Characene" originated from the name of the capital of the kingdom, Charax Spasinu. The kingdom was also known by the older name of the region, "Mesene", which is seemingly of Persian origin, meaning "land of buffalos" or the "land of sheep." The capital of Characene, Alexandria, was originally founded by the Macedonian ruler Alexander the Great, with the intention of using the town as a leading commercial port for his eastern capital of Babylon. The region itself became the Satrapy of the Erythraean Sea. However, the city never lived up to its expectations, and was destroyed in the mid 3rd-century BC by floods. It was not until the reign of the Seleucid king Antiochus IV Epiphanes (175-164 BC) that the city was rebuilt and renamed Antiochia. After the city was fully restored in 166/5 BC, Antiochus IV appointed Hyspaosines as governor (eparch) of Antiochia and the Satrapy of the Erythraean Sea. During this period Antiochia briefly flourished, until Antiochus IV's abrupt death in 163 BC, which weakened Seleucid authority throughout the empire. With the weakening of the Seleucids, many political entities within the empire declared independence, such as the neighbouring region of Characene, Elymais, which was situated in most of the present-day province of Khuzestan in southern Iran. Hyspaosines, although now a more or less independent ruler, remained a loyal subject of the Seleucids.